Left ventricular trabeculation in Hominidae: divergence of the human cardiac phenotype.

Animals Humans Heart Ventricles / anatomy & histology Hominidae / anatomy & histology Phenotype Echocardiography Biological Evolution Pan troglodytes / anatomy & histology Male Female

Journal

Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179

Informations de publication

Date de publication:
14 Jun 2024
Historique:
received: 19 10 2023
accepted: 02 05 2024
medline: 15 6 2024
pubmed: 15 6 2024
entrez: 14 6 2024
Statut: epublish

Résumé

Although the gross morphology of the heart is conserved across mammals, subtle interspecific variations exist in the cardiac phenotype, which may reflect evolutionary divergence among closely-related species. Here, we compare the left ventricle (LV) across all extant members of the Hominidae taxon, using 2D echocardiography, to gain insight into the evolution of the human heart. We present compelling evidence that the human LV has diverged away from a more trabeculated phenotype present in all other great apes, towards a ventricular wall with proportionally greater compact myocardium, which was corroborated by post-mortem chimpanzee (Pan troglodytes) hearts. Speckle-tracking echocardiographic analyses identified a negative curvilinear relationship between the degree of trabeculation and LV systolic twist, revealing lower rotational mechanics in the trabeculated non-human great ape LV. This divergent evolution of the human heart may have facilitated the augmentation of cardiac output to support the metabolic and thermoregulatory demands of the human ecological niche.

Identifiants

DOI: 10.1038/s42003-024-06280-9 PMID: 38877299
pubmed: 38877299
doi: 10.1038/s42003-024-06280-9
pii: 10.1038/s42003-024-06280-9
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

682

Subventions

Organisme : Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada)
ID : GR017741

Informations de copyright

© 2024. The Author(s).

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Auteurs

Bryony A Curry (BA)

Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, V1V 1V7, Canada.

Aimee L Drane (AL)

International Primate Heart Project, Cardiff Metropolitan University, Cyncoed Road, Cardiff, CF23 6XD, UK. a.l.drane@swansea.ac.uk.
Faculty of Medicine, Health and Life Sciences, Swansea University, Swansea, SA2 8PP, UK. a.l.drane@swansea.ac.uk.
ORCID: 0000-0002-5208-917X

Rebeca Atencia (R)

Jane Goodall Institute, Tchimpounga Chimpanzee Rehabilitation Centre, Pointe-Noire, Republic of Congo.

Yedra Feltrer (Y)

International Primate Heart Project, Cardiff Metropolitan University, Cyncoed Road, Cardiff, CF23 6XD, UK.

Thalita Calvi (T)

Chimfunshi Wildlife Orphanage, Solwesi Road, Chingola, Zambia.

Ellie L Milnes (EL)

Wildlife Health, Pathobiology and Population Sciences, Royal Veterinary College, University of London, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK.
Zoological Society of London, Regent's Park, London, NW1 4RY, UK.
Centre for Veterinary Wildlife Research, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, Pretoria, 0110, South Africa.
ORCID: 0000-0002-7797-2217

Sophie Moittié (S)

Tacugama Chimpanzee Sanctuary, Congo Dam Access Road, Freetown, Sierra Leone.
School of Veterinary Medicine, St. George's University, St. George's, West Indies, Grenada.

Annika Weigold (A)

Wilhelma Zoological-Botanical Gardens, Wilhelma 13, Stuttgart, 70376, Germany.

Tobias Knauf-Witzens (T)

Wilhelma Zoological-Botanical Gardens, Wilhelma 13, Stuttgart, 70376, Germany.

Arga Sawung Kusuma (A)

Borneo Orangutan Survival Foundation, Central Kalimantan Orangutan Reintroduction Project at Nyaru Menteng, Jalan Cilik Riwut km 28, Palangkaraya, 73111, Central Kalimantan, Indonesia.

Glyn Howatson (G)

Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, NE1 8ST, UK.
Water Research Group, Faculty of Natural and Environmental Sciences, North West University, Potchefstroom, 2531, South Africa.

Christopher Palmer (C)

Biological Science, University of New South Wales, Sydney, NSW, 2052, Australia.

Mike R Stembridge (MR)

Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, CF23 6XD, UK.

John E Gorzynski (JE)

Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
ORCID: 0000-0002-9034-9016

Neil D Eves (ND)

Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, V1V 1V7, Canada.

Tony G Dawkins (TG)

Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, V1V 1V7, Canada.
ORCID: 0000-0001-5203-135X

Rob E Shave (RE)

Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Kelowna, BC, V1V 1V7, Canada. rob.shave@ubc.ca.
ORCID: 0000-0002-0283-037X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Left ventricular trabeculation in Hominidae:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Left ventricular trabeculation in Hominidae:...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Ventricules cardiaques › Left ventricular trabeculation in Hominidae:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Left ventricular trabeculation in Hominidae:...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Left ventricular trabeculation in Hominidae:...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic cardiovasculaire › Tests de la fonction cardiaque › Échocardiographie › Left ventricular trabeculation in Hominidae:...
questionsmedicales.fr › Phénomènes biologiques › Évolution biologique › Left ventricular trabeculation in Hominidae:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Pan troglodytes › Left ventricular trabeculation in Hominidae:...