Paeoniflorin regulates RhoA/ROCK1 and Nrf2 pathways in PDLIM1-dependent or independent manners in oxidative stressed melanocytes.
NF-E2-Related Factor 2
/ metabolism
rho-Associated Kinases
/ metabolism
Melanocytes
/ drug effects
Humans
Glucosides
/ pharmacology
Oxidative Stress
/ drug effects
rhoA GTP-Binding Protein
/ metabolism
Hydrogen Peroxide
/ metabolism
Signal Transduction
/ drug effects
LIM Domain Proteins
/ metabolism
Monoterpenes
/ pharmacology
Cell Line
Cytoskeleton
PDLIM1
Paeoniflorin
ROCK1
RhoA
Vitiligo
Journal
Archives of dermatological research
ISSN: 1432-069X
Titre abrégé: Arch Dermatol Res
Pays: Germany
ID NLM: 8000462
Informations de publication
Date de publication:
15 Jun 2024
15 Jun 2024
Historique:
received:
18
11
2023
accepted:
19
05
2024
revised:
17
05
2024
medline:
15
6
2024
pubmed:
15
6
2024
entrez:
15
6
2024
Statut:
epublish
Résumé
The adhesive properties of vitiligo melanocytes have decreased under oxidative stress., cytoskeleton proteins can control cell adhesion. Paeoniflorin (PF) was proved to resist hydrogen peroxide (H This study was to investigate whether PF exerts anti-oxidative effect through influencing cytoskeleton markers or potential signaling pathway. Human Oxidative Stress Plus array was used to identify the differentially expressed genes between H PF increased the expressions of PDLIM1, RhoA and ROCK1 in H PF regulates RhoA/ROCK1 and Nrf2 pathways in PDLIM1-dependent or independent manners in H
Sections du résumé
BACKGROUND
BACKGROUND
The adhesive properties of vitiligo melanocytes have decreased under oxidative stress., cytoskeleton proteins can control cell adhesion. Paeoniflorin (PF) was proved to resist hydrogen peroxide (H
OBJECTIVES
OBJECTIVE
This study was to investigate whether PF exerts anti-oxidative effect through influencing cytoskeleton markers or potential signaling pathway.
METHODS
METHODS
Human Oxidative Stress Plus array was used to identify the differentially expressed genes between H
RESULTS
RESULTS
PF increased the expressions of PDLIM1, RhoA and ROCK1 in H
CONCLUSIONS
CONCLUSIONS
PF regulates RhoA/ROCK1 and Nrf2 pathways in PDLIM1-dependent or independent manners in H
Identifiants
pubmed: 38878083
doi: 10.1007/s00403-024-03154-2
pii: 10.1007/s00403-024-03154-2
doi:
Substances chimiques
NF-E2-Related Factor 2
0
rho-Associated Kinases
EC 2.7.11.1
Glucosides
0
NFE2L2 protein, human
0
ROCK1 protein, human
EC 2.7.11.1
rhoA GTP-Binding Protein
EC 3.6.5.2
peoniflorin
21AIQ4EV64
Hydrogen Peroxide
BBX060AN9V
LIM Domain Proteins
0
RHOA protein, human
124671-05-2
Monoterpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
401Subventions
Organisme : Pfizer's Global Medical Grants program
ID : 87970425
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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