Brain delivery enabled by transient blood-brain barrier disruption induced by regadenoson: a PET imaging study.
Blood-brain barrier
brain delivery
immunoPET
nanoparticle
pharmacokinetics, positron emission tomography
Journal
Expert opinion on drug delivery
ISSN: 1744-7593
Titre abrégé: Expert Opin Drug Deliv
Pays: England
ID NLM: 101228421
Informations de publication
Date de publication:
17 Jun 2024
17 Jun 2024
Historique:
medline:
17
6
2024
pubmed:
17
6
2024
entrez:
17
6
2024
Statut:
aheadofprint
Résumé
Regadenoson, an agonist of adenosine A2 receptors, enables transient blood-brain barrier (BBB) disruption. The relevance of regadenoson as a pharmacological strategy for brain delivery was investigated using in vivo PET imaging in rats. Kinetic modeling of brain PET data was performed to estimate the impact of regadenoson (0.05 mg.kg Regadenoson significantly increased the BBB penetration (+116 ± 13%, PET imaging showed the features and limitations of BBB disruption induced by regadenoson in terms of extent, regional distribution, and reversibility. Nevertheless, regadenoson enables the brain delivery of small molecules or nanoparticles in rats.
Sections du résumé
BACKGROUND
UNASSIGNED
Regadenoson, an agonist of adenosine A2 receptors, enables transient blood-brain barrier (BBB) disruption. The relevance of regadenoson as a pharmacological strategy for brain delivery was investigated using in vivo PET imaging in rats.
RESEARCH DESIGN AND METHODS
UNASSIGNED
Kinetic modeling of brain PET data was performed to estimate the impact of regadenoson (0.05 mg.kg
RESULTS
UNASSIGNED
Regadenoson significantly increased the BBB penetration (+116 ± 13%,
CONCLUSIONS
UNASSIGNED
PET imaging showed the features and limitations of BBB disruption induced by regadenoson in terms of extent, regional distribution, and reversibility. Nevertheless, regadenoson enables the brain delivery of small molecules or nanoparticles in rats.
Identifiants
pubmed: 38881261
doi: 10.1080/17425247.2024.2369765
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM