Synergistic Effect of Ceftazidime-Avibactam with Aztreonam on Carbapenemase-Positive

Background

The difficulties in attaining effective antibiotic therapy arising from the multidrug resistance of Gram-negative bacilli compel the exploration of new possibilities for synergistic interactions among existing antibiotics.

Research Design and Methods

An analysis was conducted to assess the efficacy of two antibiotic therapy regimens in the treatment of infections caused by

Results

In the group subjected to the treatment regimen involving ceftazidime-avibactam and aztreonam, as compared to alternative antibiotic combinations, a statistically lower mortality rate during the course of treatment and a faster clinical response to the administered therapy were evident.

Conclusion

The results obtained may be applicable to routine in vitro assays performed and serve as valuable guidance for the potential utilization of the positive effect of antibiotic therapy through the synergy between ceftazidime-avibactam and aztreonam. The selection of antibiotics employed in the therapy of invasive infections caused by

Informations de copyright

© 2024 Szymański et al.

Déclaration de conflit d'intérêts

The authors report no conflicts of interest in this work.