The usefulness of narrow-band Imaging (NBI) in nasopharyngeal lesions-Validation of the Ni NBI classification dedicated for vascular pattern in the nasopharynx.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2024
2024
Historique:
received:
17
08
2023
accepted:
27
03
2024
medline:
18
6
2024
pubmed:
18
6
2024
entrez:
17
6
2024
Statut:
epublish
Résumé
This study aims to explore the applicability of narrow-band imaging (NBI) involving the Ni classification for the diagnosis of nasopharyngeal mucosal lesions in order to distinguish malignant tumours (NPT) from non-malignant lesions. Each patient (n = 53) with a suspected nasopharyngeal lesion underwent a trans-nasal flexible video endoscopy with an optical filter for NBI. We assessed the suspected area using white light imaging (WLI) in terms of location and morphology as well as the vascular pattern (using Ni classification of nasopharyngeal microvessels) and surrounding tissue by using NBI. Based on the results of the NBI and WLI, patients were classified into "positive" or "negative" groups. All lesions of the nasopharynx were biopsied and submitted for final histological evaluation. NBI showed higher sensitivity, specificity, and accuracy than WLI. There was a significant correlation between the final histological result and the NBI pattern of the NPT: Chi2(1) = 31.34; p = 0.000001 and the WLI assessment of the NPT: Chi2(1) = 14.78; p = 0.00012. The assessment of the NPT in NBI using Ni NBI classification proved valuable in suspected mucosa assessment. NBI not only confirms the suspicious areas in WLI, but it also shows microlesions beyond the scope of WLI and allows for proper sampling.
Sections du résumé
BACKGROUND
BACKGROUND
This study aims to explore the applicability of narrow-band imaging (NBI) involving the Ni classification for the diagnosis of nasopharyngeal mucosal lesions in order to distinguish malignant tumours (NPT) from non-malignant lesions.
METHODS
METHODS
Each patient (n = 53) with a suspected nasopharyngeal lesion underwent a trans-nasal flexible video endoscopy with an optical filter for NBI. We assessed the suspected area using white light imaging (WLI) in terms of location and morphology as well as the vascular pattern (using Ni classification of nasopharyngeal microvessels) and surrounding tissue by using NBI. Based on the results of the NBI and WLI, patients were classified into "positive" or "negative" groups. All lesions of the nasopharynx were biopsied and submitted for final histological evaluation.
RESULTS
RESULTS
NBI showed higher sensitivity, specificity, and accuracy than WLI. There was a significant correlation between the final histological result and the NBI pattern of the NPT: Chi2(1) = 31.34; p = 0.000001 and the WLI assessment of the NPT: Chi2(1) = 14.78; p = 0.00012.
CONCLUSIONS
CONCLUSIONS
The assessment of the NPT in NBI using Ni NBI classification proved valuable in suspected mucosa assessment. NBI not only confirms the suspicious areas in WLI, but it also shows microlesions beyond the scope of WLI and allows for proper sampling.
Identifiants
pubmed: 38885230
doi: 10.1371/journal.pone.0302043
pii: PONE-D-23-23261
pmc: PMC11182514
doi:
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0302043Informations de copyright
Copyright: © 2024 Klimza et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Front Oncol. 2024 Jan 23;13:1221616
pubmed: 38322289
Lancet. 2019 Jul 6;394(10192):64-80
pubmed: 31178151
World J Gastrointest Endosc. 2012 Apr 16;4(4):151-6
pubmed: 22523617
Arch Otolaryngol Head Neck Surg. 2012 Feb;138(2):183-8
pubmed: 22351866
Eur Arch Otorhinolaryngol. 2017 Jan;274(1):355-359
pubmed: 27515705
Acta Otolaryngol. 2017 May;137(5):546-553
pubmed: 27841051
Sci Rep. 2018 Jan 11;8(1):515
pubmed: 29323235
World J Surg Oncol. 2018 Jul 4;16(1):126
pubmed: 29973209
F1000Res. 2018 Jun 18;7:759
pubmed: 30026934
Eur Arch Otorhinolaryngol. 2009 Jul;266(7):1017-23
pubmed: 18982341
Laryngoscope. 2019 Feb;129(2):429-434
pubmed: 30229933
PLoS One. 2017 Jun 29;12(6):e0180590
pubmed: 28662209
Laryngoscope. 2024 Jan;134(1):127-135
pubmed: 37254946
Eur Arch Otorhinolaryngol. 2011 Jun;268(6):801-6
pubmed: 21327999
Cancers (Basel). 2021 Jun 30;13(13):
pubmed: 34208811
Eur Arch Otorhinolaryngol. 2016 May;273(5):1207-14
pubmed: 26677852
Gut Liver. 2013 Mar;7(2):258-61
pubmed: 23560166
Ann Oncol. 2021 Apr;32(4):452-465
pubmed: 33358989
Head Neck. 2015 Aug;37(8):1096-101
pubmed: 24710736
Laryngoscope. 2018 Sep;128(9):2060-2066
pubmed: 29392723
World J Surg Oncol. 2023 Nov 30;21(1):376
pubmed: 38037075
Eur Arch Otorhinolaryngol. 2010 Sep;267(9):1423-8
pubmed: 20352239