Beta-2 Glycoprotein I IgA Isotype: An Important Consideration in Secondary Hypertension.
acute cva
anti-cardiolipin antibody
antiphospholipid antibody
autoimmune disorders
cerebro-vascular accident (stroke)
coagulation disorder
non-malignant hematology
primary antiphospholipid antibody syndrome
secondary hypertension
transient ischemic attacks
Journal
Cureus
ISSN: 2168-8184
Titre abrégé: Cureus
Pays: United States
ID NLM: 101596737
Informations de publication
Date de publication:
May 2024
May 2024
Historique:
accepted:
17
05
2024
medline:
18
6
2024
pubmed:
18
6
2024
entrez:
18
6
2024
Statut:
epublish
Résumé
Anti-beta-2 glycoprotein I antibodies are an important player in hypercoagulable states, including those that lead to antiphospholipid syndrome. Traditionally, assays have only detected IgG and IgM isotypes of this antibody. However, newer assays also detect the IgA isotype. The problem lies in the largely unknown significance of this IgA isotype. This paper describes a middle-aged male who presented with hypertensive emergency and was later found to have IgA anti-beta-2 glycoprotein I antibodies. He was treated with multiple anti-hypertensives, aspirin, and statin therapy. In addition to the case, we discuss the implications of this IgA isotype and how it may relate to antiphospholipid syndrome, despite not currently being included in the laboratory diagnostic criteria for the disease.
Identifiants
pubmed: 38887346
doi: 10.7759/cureus.60560
pmc: PMC11181235
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Pagination
e60560Informations de copyright
Copyright © 2024, Fusillo et al.
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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