Gephyrin promotes autonomous assembly and synaptic localization of GABAergic postsynaptic components without presynaptic GABA release.

Humans Membrane Proteins / metabolism gamma-Aminobutyric Acid / metabolism Receptors, GABA-A / metabolism Carrier Proteins / metabolism Presynaptic Terminals / metabolism Synapses / metabolism Synaptic Transmission / physiology Rho Guanine Nucleotide Exchange Factors / metabolism
Collybistin GABAergic synapse Gephyrin neurotransmitter release synapse formation

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
25 Jun 2024
Historique:
medline: 18 6 2024
pubmed: 18 6 2024
entrez: 18 6 2024
Statut: ppublish

Résumé

Synapses containing γ-aminobutyric acid (GABA) constitute the primary centers for inhibitory neurotransmission in our nervous system. It is unclear how these synaptic structures form and align their postsynaptic machineries with presynaptic terminals. Here, we monitored the cellular distribution of several GABAergic postsynaptic proteins in a purely glutamatergic neuronal culture derived from human stem cells, which virtually lacks any vesicular GABA release. We found that several GABA

Identifiants

DOI: 10.1073/pnas.2315100121 PMID: 38889143
pubmed: 38889143
doi: 10.1073/pnas.2315100121
doi:

Substances chimiques

gephyrin 0
Membrane Proteins 0
gamma-Aminobutyric Acid 56-12-2
Receptors, GABA-A 0
Carrier Proteins 0
Rho Guanine Nucleotide Exchange Factors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2315100121

Subventions

Organisme : HHS | NIH | National Institute of Mental Health (NIMH)
ID : R01-MH126017
Organisme : Colorado State University (CSU)
ID : Start up fund

Déclaration de conflit d'intérêts

Competing interests statement:The authors declare no competing interest.

Auteurs

Etta Carricaburu (E)

Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523.

Orion Benner (O)

Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523.

Scott R Burlingham (SR)

Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523.

Carolina Dos Santos Passos (C)

Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523.
ORCID: 0000-0002-5783-911X

Natalia Hobaugh (N)

Biological Sciences Division, University of Chicago, Chicago, IL 60637.

Charles H Karr (CH)

Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523.

Soham Chanda (S)

Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523.
Molecular, Cellular and Integrated Neurosciences Program, Colorado State University, Fort Collins, CO 80523.
Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523.
ORCID: 0000-0002-2327-6224

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gephyrin promotes autonomous assembly and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Gephyrin promotes autonomous assembly and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Gephyrin promotes autonomous assembly and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-A › Gephyrin promotes autonomous assembly and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de transport › Gephyrin promotes autonomous assembly and...
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Terminaisons présynaptiques › Gephyrin promotes autonomous assembly and...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › Gephyrin promotes autonomous assembly and...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Transmission synaptique › Gephyrin promotes autonomous assembly and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Facteurs d'échange de nucléotides guanyliques › Rho guanine nucleotide exchange factors › Gephyrin promotes autonomous assembly and...