Pre-emptive detection and evolution of relapse in acute myeloid leukemia by flow cytometric measurable residual disease surveillance.


Journal

Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895

Informations de publication

Date de publication:
18 Jun 2024
Historique:
received: 22 02 2024
accepted: 31 05 2024
revised: 29 05 2024
medline: 19 6 2024
pubmed: 19 6 2024
entrez: 18 6 2024
Statut: aheadofprint

Résumé

Measurable residual disease (MRD) surveillance in acute myeloid leukemia (AML) may identify patients destined for relapse and thus provide the option of pre-emptive therapy to improve their outcome. Whilst flow cytometric MRD (Flow-MRD) can be applied to high-risk AML/ myelodysplasia patients, its diagnostic performance for detecting impending relapse is unknown. We evaluated this in a cohort comprising 136 true positives (bone marrows preceding relapse by a median of 2.45 months) and 155 true negatives (bone marrows during sustained remission). At an optimal Flow-MRD threshold of 0.040%, clinical sensitivity and specificity for relapse was 74% and 87% respectively (51% and 98% for Flow-MRD ≥ 0.1%) by 'different-from-normal' analysis. Median relapse kinetics were 0.78 log

Identifiants

pubmed: 38890448
doi: 10.1038/s41375-024-02300-z
pii: 10.1038/s41375-024-02300-z
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s).

Références

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Auteurs

Nicholas McCarthy (N)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

Gege Gui (G)

Laboratory of Myeloid Malignancies, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Florent Dumezy (F)

Laboratory of Hematology, Lille University Hospital, Lille, France.

Christophe Roumier (C)

Laboratory of Hematology, Lille University Hospital, Lille, France.

Georgia Andrew (G)

Laboratory of Myeloid Malignancies, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Sarah Green (S)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

Madeleine Jenkins (M)

Imperial College, London, UK.

Alexandra Adams (A)

University of Edinburgh, Edinburgh, UK.

Naeem Khan (N)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.

Charles Craddock (C)

Clinical Trials Unit, University of Warwick, Coventry, UK.

Christopher S Hourigan (CS)

Laboratory of Myeloid Malignancies, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Adriana Plesa (A)

Lyon University Hospital, CHU-HCL, Lyon Sud, Pierre Benite, France.

Sylvie Freeman (S)

Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. s.freeman@bham.ac.uk.

Classifications MeSH