Cognitive reserve involves decision making and is associated with left parietal and hippocampal hypertrophy in neurodegeneration.
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
18 Jun 2024
18 Jun 2024
Historique:
received:
27
11
2023
accepted:
05
06
2024
medline:
19
6
2024
pubmed:
19
6
2024
entrez:
18
6
2024
Statut:
epublish
Résumé
Cognitive reserve is the ability to actively cope with brain deterioration and delay cognitive decline in neurodegenerative diseases. It operates by optimizing performance through differential recruitment of brain networks or alternative cognitive strategies. We investigated cognitive reserve using Huntington's disease (HD) as a genetic model of neurodegeneration to compare premanifest HD, manifest HD, and controls. Contrary to manifest HD, premanifest HD behave as controls despite neurodegeneration. By decomposing the cognitive processes underlying decision making, drift diffusion models revealed a response profile that differs progressively from controls to premanifest and manifest HD. Here, we show that cognitive reserve in premanifest HD is supported by an increased rate of evidence accumulation compensating for the abnormal increase in the amount of evidence needed to make a decision. This higher rate is associated with left superior parietal and hippocampal hypertrophy, and exhibits a bell shape over the course of disease progression, characteristic of compensation.
Identifiants
pubmed: 38890487
doi: 10.1038/s42003-024-06416-x
pii: 10.1038/s42003-024-06416-x
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
741Subventions
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-17-EURE-0017
Organisme : Agence Nationale de la Recherche (French National Research Agency)
ID : ANR-11-JSH2-006-1
Informations de copyright
© 2024. The Author(s).
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