Comparative Bioinformatic Analysis Reveals Conserved Regions in SARS-CoV-2 Genome for RAPID Pandemic Response.

SARS-CoV-2 bioinformatic analysis conserved genomic regions diagnostic assay point-of-care testing rapid testing

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
25 May 2024
Historique:
received: 27 03 2024
revised: 09 05 2024
accepted: 10 05 2024
medline: 19 6 2024
pubmed: 19 6 2024
entrez: 19 6 2024
Statut: epublish

Résumé

In the face of the SARS-CoV-2 pandemic, characterized by the virus's rapid mutation rates, developing timely and targeted therapeutic and diagnostic interventions presents a significant challenge. This study utilizes bioinformatic analyses to pinpoint conserved genomic regions within SARS-CoV-2, offering a strategic advantage in the fight against this and future pathogens. Our approach has enabled the creation of a diagnostic assay that is not only rapid, reliable, and cost-effective but also possesses a remarkable capacity to detect a wide array of current and prospective variants with unmatched precision. The significance of our findings lies in the demonstration that focusing on these conserved genomic sequences can significantly enhance our preparedness for and response to emerging infectious diseases. By providing a blueprint for the development of versatile diagnostic tools and therapeutics, this research paves the way for a more effective global pandemic response strategy.

Identifiants

pubmed: 38891951
pii: ijms25115764
doi: 10.3390/ijms25115764
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Marcela Viviana Karpuj (MV)

Department of Biotechnology Engineering, Braude College of Engineering, Karmiel 2161002, Israel.

D R Shaytov (DR)

Department of Biotechnology Engineering, Braude College of Engineering, Karmiel 2161002, Israel.

Yonat Shemer-Avni (Y)

Laboratory of Clinical Virology, Soroka University Medical Center, Beer-Sheva 84101, Israel.

Michael Gideon (M)

Department of Neurosurgery, Soroka Medical Center, Beer-Sheva 84101, Israel.

Zakharia M Frenkel (ZM)

Department of Software Engineering, Braude College of Engineering, Karmiel 2161002, Israel.

Sarit Sivan (S)

Department of Biotechnology Engineering, Braude College of Engineering, Karmiel 2161002, Israel.

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