Fatty Acid Synthase as Interacting Anticancer Target of the Terpenoid Myrianthic Acid Disclosed by MS-Based Proteomics Approaches.

Humans Molecular Docking Simulation Proteomics / methods Fatty Acid Synthases / metabolism Triterpenes / pharmacology Antineoplastic Agents / pharmacology Mass Spectrometry Cell Line, Tumor Cell Proliferation / drug effects Terpenes / chemistry
DARTS drug discovery fatty acid synthase functional proteomics molecular docking preclinical investigations t-LiP

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
29 May 2024
Historique:
received: 24 04 2024
revised: 23 05 2024
accepted: 25 05 2024
medline: 19 6 2024
pubmed: 19 6 2024
entrez: 19 6 2024
Statut: epublish

Résumé

This research focuses on the target deconvolution of the natural compound myrianthic acid, a triterpenoid characterized by an ursane skeleton isolated from the roots of

Identifiants

DOI: 10.3390/ijms25115918 PMID: 38892106
pubmed: 38892106
pii: ijms25115918
doi: 10.3390/ijms25115918
pii:
doi:

Substances chimiques

Fatty Acid Synthases EC 2.3.1.85
Triterpenes 0
Antineoplastic Agents 0
Terpenes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : FARB 2022
ID : ORSA22727
Organisme : PRIN2022-PNRR project
ID : P2022CKMPW

Auteurs

Alessandra Capuano (A)

Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
PhD Program in Drug Discovery and Development, Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.

Gilda D'Urso (G)

Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
ORCID: 0000-0002-4407-2781

Erica Gazzillo (E)

Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
PhD Program in Drug Discovery and Development, Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.

Gianluigi Lauro (G)

Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
ORCID: 0000-0001-5065-9717

Maria Giovanna Chini (MG)

Department of Biosciences and Territory, University of Molise, C.da Fonte Lappone, 86090 Pesche, Italy.

Maria Valeria D'Auria (MV)

Department of Pharmacy, University of Naples "Federico II", Via Domenico Montesano 49, 80131 Naples, Italy.

Maria Grazia Ferraro (MG)

Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, 80131 Naples, Italy.
ORCID: 0000-0002-3022-1205

Federica Iazzetti (F)

Biochem Lab, Department of Pharmacy, School of Medicine and Surgery, University of Naples "Federico II", Via Domenico Montesano 49, 80131 Naples, Italy.

Carlo Irace (C)

Biochem Lab, Department of Pharmacy, School of Medicine and Surgery, University of Naples "Federico II", Via Domenico Montesano 49, 80131 Naples, Italy.
ORCID: 0000-0002-5172-4573

Giuseppe Bifulco (G)

Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.

Agostino Casapullo (A)

Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.
ORCID: 0000-0002-2310-9426

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fatty Acid Synthase as Interacting Anticancer...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Fatty Acid Synthase as Interacting Anticancer...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Fatty Acid Synthase as Interacting Anticancer...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Acyltransferases › Acyl-carrier protein S-malonyltransferase › Fatty acid synthases › Fatty Acid Synthase as Interacting Anticancer...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Triterpènes › Fatty Acid Synthase as Interacting Anticancer...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Fatty Acid Synthase as Interacting Anticancer...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Fatty Acid Synthase as Interacting Anticancer...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Fatty Acid Synthase as Interacting Anticancer...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Fatty Acid Synthase as Interacting Anticancer...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Fatty Acid Synthase as Interacting Anticancer...