On the Cholesterol Raising Effect of Coffee Diterpenes Cafestol and 16-

Diterpenes / pharmacology Receptors, Cytoplasmic and Nuclear / metabolism Cholesterol / metabolism Humans Coffee / chemistry Molecular Docking Simulation Protein Binding Molecular Dynamics Simulation Circular Dichroism
16-O-methylcafestol FXR cafestol circular dichroism coffee fluorescence

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
31 May 2024
Historique:
received: 02 05 2024
revised: 24 05 2024
accepted: 27 05 2024
medline: 19 6 2024
pubmed: 19 6 2024
entrez: 19 6 2024
Statut: epublish

Résumé

The diterpene cafestol represents the most potent cholesterol-elevating compound known in the human diet, being responsible for more than 80% of the effect of coffee on serum lipids, with a mechanism still not fully clarified. In the present study, the interaction of cafestol and 16-

Identifiants

DOI: 10.3390/ijms25116096 PMID: 38892285
pubmed: 38892285
pii: ijms25116096
doi: 10.3390/ijms25116096
pii:
doi:

Substances chimiques

cafestol AC465T6Q6W
Diterpenes 0
farnesoid X-activated receptor 0C5V0MRU6P
Receptors, Cytoplasmic and Nuclear 0
Cholesterol 97C5T2UQ7J
Coffee 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Elena Guercia (E)

Aromalab, illycaffè S.p.A., Area Science Park, Località Padriciano 99, 34149 Trieste, Italy.
ORCID: 0000-0003-3271-8589

Federico Berti (F)

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy.
ORCID: 0000-0001-5608-3798

Rita De Zorzi (R)

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy.
ORCID: 0000-0001-7001-7498

Luciano Navarini (L)

Aromalab, illycaffè S.p.A., Area Science Park, Località Padriciano 99, 34149 Trieste, Italy.
ORCID: 0000-0002-9539-7500

Silvano Geremia (S)

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy.
ORCID: 0000-0002-0711-5113

Barbara Medagli (B)

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy.

Marco De Conto (M)

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy.
ORCID: 0009-0008-9012-7158

Alberto Cassetta (A)

CNR-Institute of Crystallography, Area Science Park, SS. 14, Km 163.5, Basovizza, 34149 Trieste, Italy.
ORCID: 0000-0002-8600-4162

Cristina Forzato (C)

Department of Chemical and Pharmaceutical Sciences, University of Trieste, Via Giorgieri 1, 34127 Trieste, Italy.
ORCID: 0000-0003-4213-9089

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Diterpènes › On the Cholesterol Raising Effect of Coffee...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › On the Cholesterol Raising Effect of Coffee...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › On the Cholesterol Raising Effect of Coffee...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › On the Cholesterol Raising Effect of Coffee...
questionsmedicales.fr › Aliments et boissons › Boissons › Café › On the Cholesterol Raising Effect of Coffee...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › On the Cholesterol Raising Effect of Coffee...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › On the Cholesterol Raising Effect of Coffee...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › On the Cholesterol Raising Effect of Coffee...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Dichroïsme circulaire › On the Cholesterol Raising Effect of Coffee...