Structure-Activity Relationship Studies in a Series of Xanthine Inhibitors of SLACK Potassium Channels.

Structure-Activity Relationship Humans Potassium Channel Blockers / chemistry Potassium Channels, Sodium-Activated Nerve Tissue Proteins / antagonists & inhibitors Xanthine / chemistry Patch-Clamp Techniques HEK293 Cells Molecular Structure Xanthines / chemistry
CNS EIMFS KCNT1 KNa1.1 MMPSI SLACK Slo2.2 epilepsy neuroscience xanthine

Journal

Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009

Informations de publication

Date de publication:
22 May 2024
Historique:
received: 30 04 2024
revised: 17 05 2024
accepted: 20 05 2024
medline: 19 6 2024
pubmed: 19 6 2024
entrez: 19 6 2024
Statut: epublish

Résumé

Gain-of-function mutations in the

Identifiants

DOI: 10.3390/molecules29112437 PMID: 38893312
pubmed: 38893312
pii: molecules29112437
doi: 10.3390/molecules29112437
pii:
doi:

Substances chimiques

Potassium Channel Blockers 0
Potassium Channels, Sodium-Activated 0
KCNT1 protein, human 0
Nerve Tissue Proteins 0
Xanthine 1AVZ07U9S7
Xanthines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : 1R33NS109521-03A1
Pays : United States
Organisme : Deerfield Management Company, L.P.
ID : N/A

Auteurs

Alshaima'a M Qunies (AM)

Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
ORCID: 0000-0003-4922-8682

Brittany D Spitznagel (BD)

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
ORCID: 0000-0003-4172-4147

Yu Du (Y)

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Vanderbilt Institute for Chemical Biology, Vanderbilt University, Nashville, TN 37232, USA.

Paul K Peprah (PK)

Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.

Yasmeen K Mohamed (YK)

Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
ORCID: 0009-0005-3623-6335

C David Weaver (CD)

Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Vanderbilt Institute for Chemical Biology, Vanderbilt University, Nashville, TN 37232, USA.
ORCID: 0000-0002-6886-1195

Kyle A Emmitte (KA)

Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
ORCID: 0000-0002-6643-3947

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Structure-Activity Relationship Studies in a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structure-Activity Relationship Studies in a...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Inhibiteurs des canaux potassiques › Structure-Activity Relationship Studies in a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques activés par le sodium › Structure-Activity Relationship Studies in a...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Structure-Activity Relationship Studies in a...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Xanthines › Xanthine › Structure-Activity Relationship Studies in a...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Techniques de patch-clamp › Structure-Activity Relationship Studies in a...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Structure-Activity Relationship Studies in a...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Structure-Activity Relationship Studies in a...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Purinones › Xanthines › Structure-Activity Relationship Studies in a...