Lead Identification of Novel Naphthyridine Derivatives as Potent SOS1 Inhibitors.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
13 Jun 2024
13 Jun 2024
Historique:
received:
08
04
2024
revised:
21
05
2024
accepted:
22
05
2024
pmc-release:
13
06
2025
medline:
19
6
2024
pubmed:
19
6
2024
entrez:
19
6
2024
Statut:
epublish
Résumé
SOS1, a guanine nucleotide exchange factor (GEF), plays a critical role in catalyzing the conversion of KRAS from its GDP- to GTP-bound form, regardless of
Identifiants
pubmed: 38894918
doi: 10.1021/acsmedchemlett.4c00156
pmc: PMC11181497
doi:
Types de publication
Journal Article
Langues
eng
Pagination
958-964Informations de copyright
© 2024 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.