Greater physical fitness (

aging brain age locus Coeruleus; neuroimaging neuromodulators voxel‐based morphometry

Journal

Acta physiologica (Oxford, England)
ISSN: 1748-1716
Titre abrégé: Acta Physiol (Oxf)
Pays: England
ID NLM: 101262545

Informations de publication

Date de publication:
19 Jun 2024
Historique:
revised: 30 05 2024
received: 25 04 2024
accepted: 04 06 2024
medline: 19 6 2024
pubmed: 19 6 2024
entrez: 19 6 2024
Statut: aheadofprint

Résumé

Physical activity (PA) is a key component for brain health and Reserve, and it is among the main dementia protective factors. However, the neurobiological mechanisms underpinning Reserve are not fully understood. In this regard, a noradrenergic (NA) theory of cognitive reserve (Robertson, 2013) has proposed that the upregulation of NA system might be a key factor for building reserve and resilience to neurodegeneration because of the neuroprotective role of NA across the brain. PA elicits an enhanced catecholamine response, in particular for NA. By increasing physical commitment, a greater amount of NA is synthetised in response to higher oxygen demand. More physically trained individuals show greater capabilities to carry oxygen resulting in greater We hypothesized that greater As hypothesized, greater This newly established link between

Identifiants

pubmed: 38895950
doi: 10.1111/apha.14191
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e14191

Subventions

Organisme : This work was also supported by ProApto which partly funded the study
Organisme : the National Institutes of Health (RC1-AG035954)
Organisme : Project founded by the Irish Research Council-Irish Research Council Laureate Consolidator Award (2018-23) IRCLA/2017/306 to Paul Dockree.

Informations de copyright

© 2024 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd.

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Auteurs

Emanuele R G Plini (ERG)

Department of Psychology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

Michael C Melnychuk (MC)

Department of Psychology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

Ralph Andrews (R)

Department of Psychology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

Rory Boyle (R)

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

Robert Whelan (R)

Department of Psychology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

Jeffrey S Spence (JS)

Center for BrainHealth, The University of Texas at Dallas, Dallas, Texas, USA.

Sandra B Chapman (SB)

Center for BrainHealth, The University of Texas at Dallas, Dallas, Texas, USA.

Ian H Robertson (IH)

Department of Psychology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Department of Psychology, Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.

Paul M Dockree (PM)

Department of Psychology, Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.

Classifications MeSH