RNA therapy for oncogenic NRAS-driven naevi induces apoptosis.

melanocyte nanoparticle oncogene siRNA skin

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
13 Jun 2024
Historique:
received: 10 11 2023
revised: 04 04 2024
accepted: 16 04 2024
medline: 20 6 2024
pubmed: 20 6 2024
entrez: 19 6 2024
Statut: aheadofprint

Résumé

RAS proteins regulate cell division, differentiation and apoptosis via multiple downstream effector pathways. Oncogenic RAS variants are the commonest drivers in cancers, however they also drive many benign lesions predisposing to malignancy, such as melanocytic naevi, thyroid nodules, and colonic polyps. Reversal of these benign lesions could reduce cancer incidence, however the effects of oncogenic RAS have been notoriously difficult to target with downstream pathway inhibitors. Here we show effective suppression of oncogenic and currently undruggable NRAS

Identifiants

DOI: 10.1016/j.jid.2024.04.031 PMID: 38897541
pubmed: 38897541
pii: S0022-202X(24)00449-4
doi: 10.1016/j.jid.2024.04.031
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Dale Bryant (D)

Mosaicism and Precision Medicine Lab, The Francis Crick Institute, London, UK; Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

Sara Barberan-Martin (S)

Mosaicism and Precision Medicine Lab, The Francis Crick Institute, London, UK; Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

Ruhina Maeshima (R)

Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

Ignacio Del Valle Torres (IDV)

Mosaicism and Precision Medicine Lab, The Francis Crick Institute, London, UK; Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

Mohammad Rabii (M)

Mosaicism and Precision Medicine Lab, The Francis Crick Institute, London, UK; Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

William Baird (W)

Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

Aimie Sauvadet (A)

Mosaicism and Precision Medicine Lab, The Francis Crick Institute, London, UK; Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

Charalambos Demetriou (C)

Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

Phoebe Jones (P)

Mosaicism and Precision Medicine Lab, The Francis Crick Institute, London, UK; Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

Nicole Knöpfel (N)

Mosaicism and Precision Medicine Lab, The Francis Crick Institute, London, UK; Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK; Paediatric Dermatology, Great Ormond Street Hospital for Children, London, UK.

Fanourios Michailidis (F)

Mosaicism and Precision Medicine Lab, The Francis Crick Institute, London, UK; Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

Melissa Riachi (M)

Mosaicism and Precision Medicine Lab, The Francis Crick Institute, London, UK; Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

Dorothy C Bennett (DC)

St George's University of London, London, UK.

Davide Zecchin (D)

Mosaicism and Precision Medicine Lab, The Francis Crick Institute, London, UK; Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

Alan Pittman (A)

St George's University of London, London, UK.

Satyamaanasa Polubothu (S)

Mosaicism and Precision Medicine Lab, The Francis Crick Institute, London, UK; Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK; Paediatric Dermatology, Great Ormond Street Hospital for Children, London, UK.

Stephen Hart (S)

Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK.

Veronica A Kinsler (VA)

Mosaicism and Precision Medicine Lab, The Francis Crick Institute, London, UK; Genetics and Genomic Medicine, UCL GOS Institute of Child Health, London, UK; Paediatric Dermatology, Great Ormond Street Hospital for Children, London, UK. Electronic address: v.kinsler@ucl.ac.uk.

Classifications MeSH