Approach to fever in children.

fever lymphadenopathy rash unknown origin without localising signs

Journal

Indian journal of medical microbiology
ISSN: 1998-3646
Titre abrégé: Indian J Med Microbiol
Pays: United States
ID NLM: 8700903

Informations de publication

Date de publication:
17 Jun 2024
Historique:
received: 18 04 2024
revised: 14 06 2024
accepted: 15 06 2024
medline: 20 6 2024
pubmed: 20 6 2024
entrez: 19 6 2024
Statut: aheadofprint

Résumé

Fever in children is one of the most common reasons for outpatient visits as well as in-patient evaluation, often causing anxiety among parents and caregivers. Fever can be a standalone feature or be associated with other localising symptoms and signs like rash, lymphadenopathy, or any other organ system involvement with or without a focus of infection. The etiologies of fever vary depending on the clinical setting and epidemiology. India being a tropical country, sees a distinct spectrum of tropical infections. Physicians need to stay updated on the prevalent diseases in their region and the unique factors that may influence the clinical presentations and course of fever in the cohort of children they manage. The challenge lies in balancing the benefit of early treatment for severe diseases versus the harms of unnecessary investigations and treatment for self-resolving illnesses. This review aims to provide a comprehensive overview of fever in children, covering its etiology, clinical features, and management strategies. This review offers an algorithmic approach to fever tailored to the Indian setting to guide physicians in identifying the disease based on clinical symptoms and signs, ordering essential laboratory investigations, and initiating appropriate management promptly. The review categorises fever into various segments like fever with localising signs like rash, lymphadenopathy, fever due to infection localised to a particular organ system, and fever without a focus including fever of unknown origin. It delves into the diverse etiological factors contributing to fever in each of these categories, encompassing infectious and non-infectious origins. It gives pointers to identify the etiology from history, examination, and confirm them with judicious use of diagnostic investigations with emphasis on identifying the red flag signs that require immediate attention, especially in vulnerable groups like neonates and young infants.

Sections du résumé

BACKGROUND BACKGROUND
Fever in children is one of the most common reasons for outpatient visits as well as in-patient evaluation, often causing anxiety among parents and caregivers. Fever can be a standalone feature or be associated with other localising symptoms and signs like rash, lymphadenopathy, or any other organ system involvement with or without a focus of infection. The etiologies of fever vary depending on the clinical setting and epidemiology. India being a tropical country, sees a distinct spectrum of tropical infections. Physicians need to stay updated on the prevalent diseases in their region and the unique factors that may influence the clinical presentations and course of fever in the cohort of children they manage. The challenge lies in balancing the benefit of early treatment for severe diseases versus the harms of unnecessary investigations and treatment for self-resolving illnesses.
OBJECTIVES OBJECTIVE
This review aims to provide a comprehensive overview of fever in children, covering its etiology, clinical features, and management strategies. This review offers an algorithmic approach to fever tailored to the Indian setting to guide physicians in identifying the disease based on clinical symptoms and signs, ordering essential laboratory investigations, and initiating appropriate management promptly.
CONTENT BACKGROUND
The review categorises fever into various segments like fever with localising signs like rash, lymphadenopathy, fever due to infection localised to a particular organ system, and fever without a focus including fever of unknown origin. It delves into the diverse etiological factors contributing to fever in each of these categories, encompassing infectious and non-infectious origins. It gives pointers to identify the etiology from history, examination, and confirm them with judicious use of diagnostic investigations with emphasis on identifying the red flag signs that require immediate attention, especially in vulnerable groups like neonates and young infants.

Identifiants

pubmed: 38897571
pii: S0255-0857(24)00125-7
doi: 10.1016/j.ijmmb.2024.100650
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

100650

Informations de copyright

Copyright © 2024 Indian Association of Medical Microbiologists. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Muralidharan Jayashree (M)

Division of Pediatric Critical Care, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh. Electronic address: mjshree@hotmail.com.

Narayanan Parameswaran (N)

Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry. Electronic address: narayanan.p@jipmer.edu.in.

Karthi Nallasamy (K)

Division of Pediatric Critical Care, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh. Electronic address: ny.karthi@gmail.com.

Aakash Chandran Chidambaram (AC)

Division of Pediatric Critical Care, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh. Electronic address: aakashchandran1@gmail.com.

Raajashri Rajasegar (R)

Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry. Electronic address: raajashri28@gmail.com.

Rahul Dhodapkar (R)

Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry. Electronic address: rahuldhodapkar@gmail.com.

Mala Chhabra (M)

Department of Microbiology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital (RML), Delhi. Electronic address: malachhabra@yahoo.co.in.

Nivedita Gupta (N)

Division of Communicable Diseases, ICMR Headquarters, New Delhi. Electronic address: guptanivedita.hq@icmr.gov.in.

Harmanmeet Kaur (H)

Division of Communicable Diseases, ICMR Headquarters, New Delhi. Electronic address: harmanmeet.kaur@gmail.com.

Anoop Velayudhan (A)

Division of Communicable Diseases, ICMR Headquarters, New Delhi. Electronic address: anoopvel@gmail.com.

Saumya Deol (S)

Division of Communicable Diseases, ICMR Headquarters, New Delhi. Electronic address: saumyadeol.icmr@gmail.com.

Rakesh Lodha (R)

Division of Pediatric Pulmonology& Intensive Care, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi. Electronic address: rakesh_lodha@hotmail.com.

Ravi V (R)

Department of Neurovirology, Registrar & Dean (Basic Sciences), NIMHANS Bengaluru. Electronic address: virusravi@gmail.com.

Valsan Philip Verghese (VP)

Pediatric Infectious Diseases, Christian Medical College, Vellore. Electronic address: valsan@cmcvellore.ac.in.

Winsley Rose (W)

Pediatric Infectious Diseases, Christian Medical College, Vellore. Electronic address: winsleyrose@cmcvellore.ac.in.

Classifications MeSH