Diagnosis of Post-Hematopoietic Stem Cell Transplantation Bronchiolitis Obliterans Syndrome in Children: Time for a Rethink?

bronchiolitis obliterans bronchiolitis obliterans syndrome pediatrics stem cell transplantation

Journal

Transplantation and cellular therapy
ISSN: 2666-6367
Titre abrégé: Transplant Cell Ther
Pays: United States
ID NLM: 101774629

Informations de publication

Date de publication:
01 Jun 2024
Historique:
received: 06 03 2024
revised: 28 04 2024
accepted: 13 05 2024
medline: 20 6 2024
pubmed: 20 6 2024
entrez: 19 6 2024
Statut: aheadofprint

Résumé

Hematopoietic stem cell transplantation (HSCT) is undertaken in children with the aim of curing a range of malignant and nonmalignant conditions. Unfortunately, pulmonary complications, especially bronchiolitis obliterans syndrome (BOS), are significant sources of morbidity and mortality post-HSCT. Currently, criteria developed by a National Institutes of Health (NIH) working group are used to diagnose BOS in children post-HSCT. Unfortunately, during the development of a recent American Thoracic Society (ATS) Clinical Practice Guideline on this topic, it became apparent that the NIH criteria have significant limitations in the pediatric population, leading to late diagnosis of BOS. Specific limitations include use of an outdated pulmonary function testing reference equation, a reliance on spirometry, use of a fixed forced expiratory volume in 1 second (FEV

Identifiants

DOI: 10.1016/j.jtct.2024.05.012 PMID: 38897861
pubmed: 38897861
pii: S2666-6367(24)00411-1
doi: 10.1016/j.jtct.2024.05.012
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.

Auteurs

Shivanthan Shanthikumar (S)

Respiratory and Sleep Medicine, Royal Children's Hospital, Melbourne, Australia; Respiratory Diseases, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Australia. Electronic address: shivanthan.shanthikumar@rch.org.au.

William A Gower (WA)

Division of Pulmonology, Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, North Carolina.

Kenneth R Cooke (KR)

Department of Oncology, Pediatric Blood and Marrow Transplantation Program, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland.

Anne Bergeron (A)

Pneumology Department, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.

Kirk R Schultz (KR)

Pediatric Hematology/Oncology/BMT, BC Children's Research Institute/UBC, Vancouver, British Columbia, Canada.

Amisha Barochia (A)

Laboratory of Asthma and Lung Inflammation, Critical Care Medicine and Pulmonary Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland.

Maximiliano Tamae-Kakazu (M)

Division of Pulmonary and Critical Care, Corewell Health, Grand Rapids, Michigan; Department of Medicine, Michigan State University College of Human Medicine, Michigan.

Edward Charbek (E)

Department of Internal Medicine, Saint Louis University, St Louis, Missouri.

Erin E Reardon (EE)

Woodruff Health Sciences Center Library, Emory University, Atlanta, Georgia.

Charlotte Calvo (C)

Pediatric Hematology and Immunology Department, Robert Debré Hospital, Paris Cité University, Paris, France; Human Immunology, Pathophysiology and Immunotherapy, INSERM UMR-976, Institut de Recherche Saint-Louis, Paris, France.

Alicia Casey (A)

Division of Pulmonary Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Pi Chun Cheng (PC)

Division of Pediatric Pulmonology, Allergy, and Sleep Medicine, Riley Hospital for Children, Indianapolis, Indiana; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.

Theresa S Cole (TS)

Department of Paediatrics, University of Melbourne, Melbourne, Australia; Children's Cancer Centre, Royal Children's Hospital, Melbourne, Australia; Infection & immunity, Murdoch Children's Research Institute, Melbourne, Australia.

Stella M Davies (SM)

Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.

Shailendra Das (S)

Department of Pediatrics, Baylor College of Medicine, Houston, Texas.

Alive De (A)

Division of Pediatric Pulmonology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York.

Robin R Deterding (RR)

Chief Pediatric Pulmonary and Sleep Medicine, University of Colorado and Children's Hospital Colorado, Aurora, Colorado.

Deborah R Liptzin (DR)

Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington.

Francoise Mechinaud (F)

Pediatric Hematology and Immunology Department, Robert Debré Hospital, Paris Cité University, Paris, France.

Jonathan H Rayment (JH)

Division of Respiratory Medicine, BC Children's Hospital, Vancouver, Canada; Department of Pediatrics, University of British Columbia, Vancouver, Canada.

Paul D Robinson (PD)

Department of Respiratory Medicine, Queensland Children's Hospital, Queensland, Australia; Children's Health and Environment Program, Child Health Research Centre, University of Queensland, Queensland, Australia; Airway Physiology and Imaging Group, Woolcock Institute of Medical Research, New South Wales, Australia.

Roopa Siddaiah (R)

Division of Pulmonology, Department of Pediatrics, Penn State Health Children's Hospital, Hershey, Pennsylvania.

Anne Stone (A)

Division of Pediatric Pulmonology, Department of Pediatrics, Oregon Health & Science University, Portland, Oregon.

Saumini Srinivasin (S)

Department of Pediatrics, University of Tennessee College of Medicine, Le Bonheur Children's Hospital, Memphis, Tennessee.

Christopher T Towe (CT)

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio; Division of Pulmonary Medicine, Cincinnati Children's Hospital, Cincinnati, Ohio.

Gregory A Yanik (GA)

Blood and Marrow Transplant Program, University of Michigan, Ann Arbor, Michigan.

Narayan P Iyer (NP)

Division of Neonatology, Fetal and Neonatal Institute, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California.

Samuel B Goldfarb (SB)

Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota; Division of Pulmonary Medicine, Masonic Children's Hospital, Minneapolis, Minnesota.

Classifications MeSH