Acute Type B Aortic Dissection: Insights From a Single-Center Retrospective Experience Over 12 Years.

acute aortic dissection aneurysmal degeneration aortic remodeling late aortic events stent-graft type B

Journal

Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists
ISSN: 1545-1550
Titre abrégé: J Endovasc Ther
Pays: United States
ID NLM: 100896915

Informations de publication

Date de publication:
19 Jun 2024
Historique:
medline: 20 6 2024
pubmed: 20 6 2024
entrez: 20 6 2024
Statut: aheadofprint

Résumé

The treatment of acute type B aortic dissection (ATBAD) is currently a challenge for vascular surgeons, because of the early morbidity and mortality rates and the high risk of late aortic events up to 50% at 5 years. This study presents the initial outcomes of ATBAD treatment using optimal medical therapy alone or combined with proximal entry tear stent-graft coverage. Additionally, it provides an analysis of the evolution of the aortic diameter and its clinical consequences during the chronic phase in each group. Conducted as a retrospective, single-center study, we enrolled all consecutive ATBAD patients (n=130) treated between 2008 and 2020. The primary analysis studies the entire patient cohort based on their initial management approach, namely, medical treatment alone for uncomplicated ATBAD (n=67) or combined with stent-graft entry tear coverage (n=63). We also conducted a subgroup analysis to investigate factors associated with disease progression in the medical management group. Median follow-up was 29.5 months. During this time aneurysmal evolution was observed in: 42.4% of cases in the medical group compared with 21.8% in the stent-graft group, primarily affecting the thoracic aorta. The stent-graft group exhibited significant aortic remodeling, with a decrease in false lumen (FL) and thoracic aortic diameters. Initial aortic diameter ≥40 mm and FL ≥22 mm were independent risk factors for aneurysmal degeneration. Five-year survival was consistent at 76.1% in both groups. This study confirms the safety and efficacy of stent-graft entry tear coverage for ATBAD. Initial thoracic endovascular aortic repair (TEVAR) appears to reduce late aortic events by promoting aortic remodeling. Considering TEVAR's safety and potential to prevent late aortic complications, it may be considered for uncomplicated ATBAD patients with an initial aortic diameter ≥40 mm or an FL ≥22 mm. This study validates the efficacy and safety of using endovascular stent grafts to seal the proximal entry tear in cases of acute type B aortic dissections, compared to optimal medical therapy. Aortic remodelling significantly benefits from endovascular stent graft coverage of the proximal entry tear. Given the heightened risk of late aortic events observed in the medical therapy cohort, there appears to be a necessity for including endovascular interventions in the management of uncomplicated acute type B aortic dissections, particularly when aortic diameter is ≥40 mm and false lumen diameter is ≥22 mm.

Identifiants

pubmed: 38898697
doi: 10.1177/15266028241258401
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

15266028241258401

Déclaration de conflit d'intérêts

Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Auteurs

Alexandre Azoulay (A)

Department of Vascular and Thoracic Surgery, University of Montpellier, CHU Montpellier, Montpellier, France.

Chris Serrand (C)

Biostatistics, Epidemiology, Public Health and Methodological Innovation Unit (Unité de biostatistique, épidémiologie, santé publique et innovation méthodologique, BESPIM), Nîmes University Hospital, Nîmes, France.

Amine Belarbi (A)

Department of Vascular and Thoracic Surgery, University of Montpellier, CHU Montpellier, Montpellier, France.

Pascal Branchereau (P)

Department of Vascular and Thoracic Surgery, University of Montpellier-Nimes, CHU Nimes, Nimes, France.

Giorgio Prouse (G)

Department of Vascular Surgery, Ente Ospedaliero Cantonale, Lugano, Switzerland.

Kheira Hireche (K)

Department of Vascular and Thoracic Surgery, University of Montpellier, CHU Montpellier, Montpellier, France.
PhyMedExp, University of Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France.

Ludovic Canaud (L)

Department of Vascular and Thoracic Surgery, University of Montpellier, CHU Montpellier, Montpellier, France.
PhyMedExp, University of Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France.

Pierre Alric (P)

Department of Vascular and Thoracic Surgery, University of Montpellier, CHU Montpellier, Montpellier, France.
PhyMedExp, University of Montpellier, CNRS, INSERM, CHU Montpellier, Montpellier, France.

Classifications MeSH