Hierarchical Protofilament Intertwining Rules the Formation of Mixed-Curvature Amyloid Polymorphs.
amyloid polymorphism
atomic force microscopy
filament intertwining mechanism
mixed‐curvature amyloid
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
20 Jun 2024
20 Jun 2024
Historique:
revised:
19
05
2024
received:
15
03
2024
medline:
20
6
2024
pubmed:
20
6
2024
entrez:
20
6
2024
Statut:
aheadofprint
Résumé
Amyloid polymorphism is a hallmark of almost all amyloid species, yet the mechanisms underlying the formation of amyloid polymorphs and their complex architectures remain elusive. Commonly, two main mesoscopic topologies are found in amyloid polymorphs characterized by non-zero Gaussian and mean curvatures: twisted ribbons and helical fibrils, respectively. Here, a rich heterogeneity of configurations is demonstrated on insulin amyloid fibrils, where protofilament packing can occur, besides the common polymorphs, also in a combined mode forming mixed-curvature polymorphs. Through AFM statistical analysis, an extended array of heterogeneous architectures that are rationalized by mesoscopic theoretical arguments are identified. Notably, an unusual fibrillization pathway is also unraveled toward mixed-curvature polymorphs via the widespread recruitment and intertwining of protofilaments and protofibrils. The results present an original view of amyloid polymorphism and advance the fundamental understanding of the fibrillization mechanism from single protofilaments into mature amyloid fibrils.
Identifiants
pubmed: 38899849
doi: 10.1002/advs.202402740
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2402740Subventions
Organisme : Swiss National Science Foundation
ID : CRSII5_177195
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 310030_188548
Pays : Switzerland
Organisme : Laboratory of Biological Electron Microscopy
Organisme : MCIN/AEI/ 10.13039/501100011033 and FSE +
ID : RamónyCajalFellowship
Organisme : MCIN/AEI/ 10.13039/501100011033 and FSE +
ID : ref.RYC2022-037744-I
Informations de copyright
© 2024 The Author(s). Advanced Science published by Wiley‐VCH GmbH.
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