Similar Insulin Regulation of Splanchnic FFA and VLDL-TG in Men with Nonalcoholic Hepatic Steatosis and Steatohepatitis.

VLDL free fatty acids insulin lipolysis and fatty acid metabolism lipoproteins/kinetics liver nonalcoholic fatty liver disease triglycerides visceral adipose tissue

Journal

Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606

Informations de publication

Date de publication:
18 Jun 2024
Historique:
received: 25 10 2023
revised: 10 06 2024
accepted: 14 06 2024
medline: 21 6 2024
pubmed: 21 6 2024
entrez: 20 6 2024
Statut: aheadofprint

Résumé

This study aimed to determine whether obese men with nonalcoholic fatty liver disease (NAFLD) display differences between those with simple steatosis vs. steatohepatitis (NASH) in splanchnic and hepatic FFA and VLDL-triglycerides (VLDL-TG) balances. The study involved 17 obese men with biopsy-proven NAFLD (9 with NASH and 8 with simple steatosis). We used hepatic vein catheterization in combination with [

Identifiants

DOI: 10.1016/j.jlr.2024.100580 PMID: 38901559
pubmed: 38901559
pii: S0022-2275(24)00085-3
doi: 10.1016/j.jlr.2024.100580
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

100580

Informations de copyright

Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declarations of interest none

Auteurs

Jeyanthini Risikesan (J)

Steno Diabetes Center Aarhus, Aarhus University Hospital (AUH), Aarhus, Denmark.

Sara Heebøll (S)

Steno Diabetes Center Aarhus, Aarhus University Hospital (AUH), Aarhus, Denmark; Department of Endocrinology and Internal Medicine, AUH, Aarhus, Denmark.

Indumathi Kumarathas (I)

Steno Diabetes Center Aarhus, Aarhus University Hospital (AUH), Aarhus, Denmark.

Esben Søndergaard (E)

Steno Diabetes Center Aarhus, Aarhus University Hospital (AUH), Aarhus, Denmark.

Rakel F Johansen (RF)

Steno Diabetes Center Aarhus, Aarhus University Hospital (AUH), Aarhus, Denmark.

Steffen Ringgaard (S)

MR Research Centre, Aarhus University, Aarhus, Denmark.

Niels K Aagaard (NK)

Department of Hepatology and Gastroenterology, AUH, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Thomas D Sandahl (TD)

Department of Hepatology and Gastroenterology, AUH, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Gerda E Villadsen (GE)

Department of Hepatology and Gastroenterology, AUH, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Lars C Gormsen (LC)

Department of Nuclear Medicine and PET Centre, AUH, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Jan Frystyk (J)

Department of Endocrinology, Odense University Hospital, Odense, Denmark.

Michael D Jensen (MD)

Endocrine Research Unit, Mayo Clinic, Rochester, MN, USA.

Henning Grønbæk (H)

Department of Hepatology and Gastroenterology, AUH, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Søren Nielsen (S)

Steno Diabetes Center Aarhus, Aarhus University Hospital (AUH), Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: nielsen.soren@dadlnet.dk.

Classifications MeSH