Langerhans cell histiocytosis mimicking acute dacryocystitis.
Acute dacryocystitis
BRAF mutation
Dacriocistitis aguda
Histiocitosis de células de Langerhans
Imaging studies
Immunohistochemistry
Inmunohistoquímica
Lacrimal sac
Langerhans cell histiocytosis
Mutación BRAF
Orbit
Pruebas de imagen
Saco lagrimal
Órbita
Journal
Archivos de la Sociedad Espanola de Oftalmologia
ISSN: 2173-5794
Titre abrégé: Arch Soc Esp Oftalmol (Engl Ed)
Pays: Spain
ID NLM: 101715860
Informations de publication
Date de publication:
18 Jun 2024
18 Jun 2024
Historique:
received:
04
02
2024
accepted:
14
04
2024
medline:
21
6
2024
pubmed:
21
6
2024
entrez:
20
6
2024
Statut:
aheadofprint
Résumé
Langerhans cell histiocytosis (LCH) is a myeloid neoplasm characterized by clonal neoplastic proliferation of Langerhans-type dendritic cells associated with an inflammatory infiltrate predominantly composed of lymphocytes and eosinophils. In this article, we present an unusual case of LCH with significant swelling in the left lacrimal sac region in a 3-year-old child, clinically mimicking acute dacryocystitis. Microscopically, it showed intense inflammatory infiltrate and histiocytes with irregular nuclei. The tumor cells were positive for S-100 protein, CD1a, and CD207 (langerin). Molecular study was positive for the V600E/E2/D mutation (EXON 15). This case emphasizes the importance of careful clinical, radiographic, and microscopic evaluation, as some neoplasms may mimic common benign lesions.
Identifiants
pubmed: 38901610
pii: S2173-5794(24)00104-X
doi: 10.1016/j.oftale.2024.06.003
pii:
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2024 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.