External validation of a paediatric Smart triage model for use in resource limited facilities.


Journal

PLOS digital health
ISSN: 2767-3170
Titre abrégé: PLOS Digit Health
Pays: United States
ID NLM: 9918335064206676

Informations de publication

Date de publication:
Jun 2024
Historique:
received: 05 06 2023
accepted: 24 04 2024
medline: 21 6 2024
pubmed: 21 6 2024
entrez: 21 6 2024
Statut: epublish

Résumé

Models for digital triage of sick children at emergency departments of hospitals in resource poor settings have been developed. However, prior to their adoption, external validation should be performed to ensure their generalizability. We externally validated a previously published nine-predictor paediatric triage model (Smart Triage) developed in Uganda using data from two hospitals in Kenya. Both discrimination and calibration were assessed, and recalibration was performed by optimizing the intercept for classifying patients into emergency, priority, or non-urgent categories based on low-risk and high-risk thresholds. A total of 2539 patients were eligible at Hospital 1 and 2464 at Hospital 2, and 5003 for both hospitals combined; admission rates were 8.9%, 4.5%, and 6.8%, respectively. The model showed good discrimination, with area under the receiver-operator curve (AUC) of 0.826, 0.784 and 0.821, respectively. The pre-calibrated model at a low-risk threshold of 8% achieved a sensitivity of 93% (95% confidence interval, (CI):89%-96%), 81% (CI:74%-88%), and 89% (CI:85%-92%), respectively, and at a high-risk threshold of 40%, the model achieved a specificity of 86% (CI:84%-87%), 96% (CI:95%-97%), and 91% (CI:90%-92%), respectively. Recalibration improved the graphical fit, but new risk thresholds were required to optimize sensitivity and specificity.The Smart Triage model showed good discrimination on external validation but required recalibration to improve the graphical fit of the calibration plot. There was no change in the order of prioritization of patients following recalibration in the respective triage categories. Recalibration required new site-specific risk thresholds that may not be needed if prioritization based on rank is all that is required. The Smart Triage model shows promise for wider application for use in triage for sick children in different settings.

Identifiants

pubmed: 38905166
doi: 10.1371/journal.pdig.0000293
pii: PDIG-D-23-00216
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e0000293

Informations de copyright

Copyright: © 2024 Kigo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Déclaration de conflit d'intérêts

The authors have declared that no competing interests exist.

Auteurs

Joyce Kigo (J)

Health Service Unit, Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Nairobi, Kenya.

Stephen Kamau (S)

Health Service Unit, Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Nairobi, Kenya.

Alishah Mawji (A)

Centre for International Child Health, BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.

Paul Mwaniki (P)

Health Service Unit, Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Nairobi, Kenya.

Dustin Dunsmuir (D)

Centre for International Child Health, BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.

Yashodani Pillay (Y)

Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.

Cherri Zhang (C)

Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.

Katija Pallot (K)

Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.

Morris Ogero (M)

Health Service Unit, Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Nairobi, Kenya.

David Kimutai (D)

Department of Pediatrics, Mbagathi County Hospital, Nairobi, Kenya.

Mary Ouma (M)

Department of Pediatrics, Mbagathi County Hospital, Nairobi, Kenya.

Ismael Mohamed (I)

Department of Pediatrics, Mbagathi County Hospital, Nairobi, Kenya.

Mary Chege (M)

Department of Pediatrics, Kiambu County Referral Hospital, Kiambu, Kenya.

Lydia Thuranira (L)

Department of Pediatrics, Kiambu County Referral Hospital, Kiambu, Kenya.

Niranjan Kissoon (N)

Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.

J Mark Ansermino (JM)

Centre for International Child Health, BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.

Samuel Akech (S)

Health Service Unit, Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Nairobi, Kenya.

Classifications MeSH