Parsing patterns: Emerging roles of tissue self-organization in health and disease.

Humans Animals Body Patterning Homeostasis Embryonic Development Organoids / metabolism

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
20 Jun 2024
Historique:
received: 12 09 2023
revised: 22 02 2024
accepted: 08 05 2024
medline: 22 6 2024
pubmed: 22 6 2024
entrez: 21 6 2024
Statut: ppublish

Résumé

Patterned morphologies, such as segments, spirals, stripes, and spots, frequently emerge during embryogenesis through self-organized coordination between cells. Yet, complex patterns also emerge in adults, suggesting that the capacity for spontaneous self-organization is a ubiquitous property of biological tissues. We review current knowledge on the principles and mechanisms of self-organized patterning in embryonic tissues and explore how these principles and mechanisms apply to adult tissues that exhibit features of patterning. We discuss how and why spontaneous pattern generation is integral to homeostasis and healing of tissues, illustrating it with examples from regenerative biology. We examine how aberrant self-organization underlies diverse pathological states, including inflammatory skin disorders and tumors. Lastly, we posit that based on such blueprints, targeted engineering of pattern-driving molecular circuits can be leveraged for synthetic biology and the generation of organoids with intricate patterns.

Identifiants

DOI: 10.1016/j.cell.2024.05.016 PMID: 38906093
pubmed: 38906093
pii: S0092-8674(24)00525-7
doi: 10.1016/j.cell.2024.05.016
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

3165-3186

Informations de copyright

Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

Auteurs

Raul Ramos (R)

Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA, USA.

Benjamin Swedlund (B)

Eli and Edythe Broad CIRM Center, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Anand K Ganesan (AK)

Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA; Department of Dermatology, University of California, Irvine, Irvine, CA, USA.

Leonardo Morsut (L)

Eli and Edythe Broad CIRM Center, Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Alfred E. Mann Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.

Philip K Maini (PK)

Mathematical Institute, University of Oxford, Oxford, UK.

Edwin S Monuki (ES)

Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, USA; Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, CA, USA.

Arthur D Lander (AD)

Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA. Electronic address: adlander@uci.edu.

Cheng-Ming Chuong (CM)

Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: cmchuong@med.usc.edu.

Maksim V Plikus (MV)

Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA, USA; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA, USA; NSF-Simons Center for Multiscale Cell Fate Research, University of California, Irvine, Irvine, CA, USA; Center for Complex Biological Systems, University of California, Irvine, Irvine, CA, USA. Electronic address: plikus@uci.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Parsing patterns: Emerging roles of tissue...
questionsmedicales.fr › Eucaryotes › Animaux › Parsing patterns: Emerging roles of tissue...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Morphogenèse › Plan d'organisation du corps › Parsing patterns: Emerging roles of tissue...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Parsing patterns: Emerging roles of tissue...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Parsing patterns: Emerging roles of tissue...
questionsmedicales.fr › Tissus › Organoïdes › Parsing patterns: Emerging roles of tissue...