Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL.
Journal
Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562
Informations de publication
Date de publication:
21 Jun 2024
21 Jun 2024
Historique:
received:
13
07
2023
accepted:
05
06
2024
revised:
30
05
2024
medline:
22
6
2024
pubmed:
22
6
2024
entrez:
21
6
2024
Statut:
aheadofprint
Résumé
Malignant transformation of T-cell progenitors causes T-cell acute lymphoblastic leukemia (T-ALL), an aggressive childhood lymphoproliferative disorder. Activating mutations of Notch, Notch1 and Notch3, have been detected in T-ALL patients. In this study, we aimed to deeply characterize hyperactive Notch3-related pathways involved in T-cell dynamics within the thymus and bone marrow to propose these processes as an important step in facilitating the progression of T-ALL. We previously generated a transgenic T-ALL mouse model (N3-ICtg) demonstrating that aberrant Notch3 signaling affects early thymocyte maturation programs and leads to bone marrow infiltration by CD4
Identifiants
pubmed: 38907003
doi: 10.1038/s41388-024-03079-0
pii: 10.1038/s41388-024-03079-0
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : RP123188F3C01EB7
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : RP12117A63FBA27C
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : RP122181642E92CE
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : AR123188AF112A64
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : AR222181616D9D01
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : AR1181643646B258
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : PH118164340087CF
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : RM12117A71419448
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research)
ID : ARS01_00432
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature Limited.
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