Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL.


Journal

Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562

Informations de publication

Date de publication:
21 Jun 2024
Historique:
received: 13 07 2023
accepted: 05 06 2024
revised: 30 05 2024
medline: 22 6 2024
pubmed: 22 6 2024
entrez: 21 6 2024
Statut: aheadofprint

Résumé

Malignant transformation of T-cell progenitors causes T-cell acute lymphoblastic leukemia (T-ALL), an aggressive childhood lymphoproliferative disorder. Activating mutations of Notch, Notch1 and Notch3, have been detected in T-ALL patients. In this study, we aimed to deeply characterize hyperactive Notch3-related pathways involved in T-cell dynamics within the thymus and bone marrow to propose these processes as an important step in facilitating the progression of T-ALL. We previously generated a transgenic T-ALL mouse model (N3-ICtg) demonstrating that aberrant Notch3 signaling affects early thymocyte maturation programs and leads to bone marrow infiltration by CD4

Identifiants

pubmed: 38907003
doi: 10.1038/s41388-024-03079-0
pii: 10.1038/s41388-024-03079-0
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : RP123188F3C01EB7
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : RP12117A63FBA27C
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : RP122181642E92CE
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : AR123188AF112A64
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : AR222181616D9D01
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : AR1181643646B258
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : PH118164340087CF
Organisme : Sapienza Università di Roma (Sapienza University of Rome)
ID : RM12117A71419448
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research)
ID : ARS01_00432

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Ilaria Sergio (I)

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Claudia Varricchio (C)

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Sandesh Kumar Patel (SK)

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Martina Del Gaizo (M)

Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Eleonora Russo (E)

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Andrea Orlando (A)

Division of Hematology & Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York NY, USA.

Giovanna Peruzzi (G)

Center for Life Nano-Neuro Science, IIT, Rome, Italy.

Francesca Ferrandino (F)

A.O.R.N. dei colli Monaldi V., Napoli, Italy.

Georgia Tsaouli (G)

Department of Medical-Surgical Science and Translational Medicine, Sapienza University of Rome, Rome, Italy.

Sonia Coni (S)

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Daniele Peluso (D)

Ph.D School of Applied Medical-Surgical Sciences, Department of Biology, University of Rome "Tor Vergata", Rome, Italy.

Zein Mersini Besharat (ZM)

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Federica Campolo (F)

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Mary Anna Venneri (MA)

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Donatella Del Bufalo (D)

Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.

Silvia Lai (S)

Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Stefano Indraccolo (S)

Department of Surgery Oncology and Gastroenterology, University of Padua, Padua, Italy.
Basic and Translational Oncology Unit, Istituto Oncologico Veneto IOV-IRCCS, Padua, Italy.

Sonia Minuzzo (S)

Department of Surgery Oncology and Gastroenterology, University of Padua, Padua, Italy.

Roberta La Starza (R)

Hematology Section, Department of Medicine and Surgery, and S. Maria Della Misericordia Hospital Perugia, CREO, Perugia, Italy.

Giovanni Bernardini (G)

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Isabella Screpanti (I)

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Antonio Francesco Campese (AF)

Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.

Maria Pia Felli (MP)

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. mariapia.felli@uniroma1.it.

Classifications MeSH