The Acoel nervous system: morphology and development.
Journal
Neural development
ISSN: 1749-8104
Titre abrégé: Neural Dev
Pays: England
ID NLM: 101286574
Informations de publication
Date de publication:
21 Jun 2024
21 Jun 2024
Historique:
received:
15
04
2024
accepted:
15
06
2024
medline:
22
6
2024
pubmed:
22
6
2024
entrez:
21
6
2024
Statut:
epublish
Résumé
Acoel flatworms have played a relevant role in classical (and current) discussions on the evolutionary origin of bilaterian animals. This is mostly derived from the apparent simplicity of their body architectures. This tenet has been challenged over the last couple of decades, mostly because detailed studies of their morphology and the introduction of multiple genomic technologies have unveiled a complexity of cell types, tissular arrangements and patterning mechanisms that were hidden below this 'superficial' simplicity. One tissue that has received a particular attention has been the nervous system (NS). The combination of ultrastructural and single cell methodologies has revealed unique cellular diversity and developmental trajectories for most of their neurons and associated sensory systems. Moreover, the great diversity in NS architectures shown by different acoels offers us with a unique group of animals where to study key aspects of neurogenesis and diversification od neural systems over evolutionary time.In this review we revisit some recent developments in the characterization of the acoel nervous system structure and the regulatory mechanisms that contribute to their embryological development. We end up by suggesting some promising avenues to better understand how this tissue is organized in its finest cellular details and how to achieve a deeper knowledge of the functional roles that genes and gene networks play in its construction.
Identifiants
pubmed: 38907301
doi: 10.1186/s13064-024-00187-1
pii: 10.1186/s13064-024-00187-1
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
9Subventions
Organisme : Spanish "Ministerio de Ciencia, Innovación y Universidades"
ID : PID2021-124415NB-I00
Organisme : Swiss National Science Foundation
ID : 310030_219348
Pays : Switzerland
Informations de copyright
© 2024. The Author(s).
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