Serologic profiling of D variants in donor routine: unveiling the impact on false-negative results and alloimmunization.
D typing discrepancy
D variants
RHD variants
anti-D
partial D
weak D
Journal
Immunohematology
ISSN: 0894-203X
Titre abrégé: Immunohematology
Pays: United States
ID NLM: 8806387
Informations de publication
Date de publication:
01 Jun 2024
01 Jun 2024
Historique:
medline:
24
6
2024
pubmed:
24
6
2024
entrez:
24
6
2024
Statut:
epublish
Résumé
The high number of D variants can lead to the unnecessary use of Rh immune globulin, overuse of D- RBC units, and anti-D allommunization. D variant prevalence varies among ethnic groups, and knowledge of the main variants present in a specific population, their behavior in serologic tests, and their impact on clinical practice is crucial to define the best serologic tests for routine use. The present study aimed to explore the serologic profile of D variants and to determine which variants are most associated with false-negative D typing results and alloimmunization. Donor samples were selected in two study periods. During the first period, D typing was performed on a semi-automated instrument in microplates, and weak D tests were conducted in tube or gel tests. In the second period, D typing was carried out using an automated instrument with microplates, and weak D tests were performed in solid phase. Samples from patients typed as D+ with anti-D were also selected. All samples were characterized by molecular testing. A total of 37
Identifiants
pubmed: 38910444
pii: immunohematology-2024-007
doi: 10.2478/immunohematology-2024-007
doi:
Substances chimiques
Rh-Hr Blood-Group System
0
Isoantibodies
0
Rho(D) Immune Globulin
0
Rho(D) antigen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
47-53Informations de copyright
© 2024 Carine P. Arnoni et al., published by Sciendo.
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