Blockage of Akt activation suppresses cadmium-induced renal tubular cellular damages through aggrephagy in HK-2 cells.
Humans
Proto-Oncogene Proteins c-akt
/ metabolism
Autophagy
/ drug effects
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
/ metabolism
Cell Line
Cadmium
/ toxicity
Kidney Tubules, Proximal
/ drug effects
Phosphorylation
/ drug effects
Cadmium Chloride
/ toxicity
Heterocyclic Compounds, 3-Ring
/ pharmacology
Kidney Tubules
/ metabolism
Aggresome
Akt
Cadmium
Cell death
Renal proximal tubular cells
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 06 2024
24 06 2024
Historique:
received:
07
02
2024
accepted:
11
06
2024
medline:
25
6
2024
pubmed:
25
6
2024
entrez:
24
6
2024
Statut:
epublish
Résumé
We have reported that an environmental pollutant, cadmium, promotes cell death in the human renal tubular cells (RTCs) through hyperactivation of a serine/threonine kinase Akt. However, the molecular mechanisms downstream of Akt in this process have not been elucidated. Cadmium has a potential to accumulate misfolded proteins, and proteotoxicity is involved in cadmium toxicity. To clear the roles of Akt in cadmium exposure-induced RTCs death, we investigated the possibility that Akt could regulate proteotoxicity through autophagy in cadmium chloride (CdCl
Identifiants
pubmed: 38914593
doi: 10.1038/s41598-024-64579-3
pii: 10.1038/s41598-024-64579-3
doi:
Substances chimiques
Proto-Oncogene Proteins c-akt
EC 2.7.11.1
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
0
Cadmium
00BH33GNGH
TFEB protein, human
0
MK 2206
0
TFE3 protein, human
0
Cadmium Chloride
J6K4F9V3BA
Heterocyclic Compounds, 3-Ring
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
14552Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19K07052
Organisme : Japan Society for the Promotion of Science
ID : 19K10582
Informations de copyright
© 2024. The Author(s).
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