Mucinous cystadenoma and carcinoid tumor arising from an ovarian mature cystic teratoma in a 60 year-old patient: a case report.
Carcinoid tumor
Malignant transformation
Mature cystic teratoma
Neuroendocrine tumor
Ovarian neoplasm
Journal
Journal of medical case reports
ISSN: 1752-1947
Titre abrégé: J Med Case Rep
Pays: England
ID NLM: 101293382
Informations de publication
Date de publication:
25 Jun 2024
25 Jun 2024
Historique:
received:
10
03
2024
accepted:
29
05
2024
medline:
25
6
2024
pubmed:
25
6
2024
entrez:
24
6
2024
Statut:
epublish
Résumé
Mature cystic teratomas (MCT) of the ovary are benign ovarian germ cell neoplasms. Malignant transformation is possible but rare and ovarian carcinoid tumors in MCT are among the most extremely rare subtypes. We report a case of a 60-year-old Iranian woman suffering from postmenopausal bleeding and hypogastric pain for the last 40 days. An adnexal mass was detected during the physical examination. Ultrasound imaging showed a (55 × 58) mm mass in the left ovary. Total abdominal hysterectomy, bilateral salpingooophorectomy and comprehensive staging surgery were performed for the patient. Intraoperative frozen section of the left ovarian mass was indicative of a malignant tumor. She was diagnosed with a carcinoid tumor with benign mucinous cystadenoma arising on MCT of the ovary, confirmed in the histopathology and immunohistochemistry examination. The tumor was classified as low grade and no chemotherapy cycles were considered. The patient was followed up long-term and no recurrence was observed during 14 months of examinations. Ovarian carcinoids arising from MCT are rare neuroendocrine neoplasms, and proper diagnosis of these tumors requires careful histopathology evaluation and appropriate examination. Therefore, it is necessary to consider these tumors as a possible differential diagnosis and evaluate them in individuals (especially postmenopausal women) who have abdominal pain or abnormal bleeding and a palpable mass.
Sections du résumé
BACKGROUND
BACKGROUND
Mature cystic teratomas (MCT) of the ovary are benign ovarian germ cell neoplasms. Malignant transformation is possible but rare and ovarian carcinoid tumors in MCT are among the most extremely rare subtypes.
CASE PRESENTATION
METHODS
We report a case of a 60-year-old Iranian woman suffering from postmenopausal bleeding and hypogastric pain for the last 40 days. An adnexal mass was detected during the physical examination. Ultrasound imaging showed a (55 × 58) mm mass in the left ovary. Total abdominal hysterectomy, bilateral salpingooophorectomy and comprehensive staging surgery were performed for the patient. Intraoperative frozen section of the left ovarian mass was indicative of a malignant tumor. She was diagnosed with a carcinoid tumor with benign mucinous cystadenoma arising on MCT of the ovary, confirmed in the histopathology and immunohistochemistry examination. The tumor was classified as low grade and no chemotherapy cycles were considered. The patient was followed up long-term and no recurrence was observed during 14 months of examinations.
CONCLUSION
CONCLUSIONS
Ovarian carcinoids arising from MCT are rare neuroendocrine neoplasms, and proper diagnosis of these tumors requires careful histopathology evaluation and appropriate examination. Therefore, it is necessary to consider these tumors as a possible differential diagnosis and evaluate them in individuals (especially postmenopausal women) who have abdominal pain or abnormal bleeding and a palpable mass.
Identifiants
pubmed: 38915051
doi: 10.1186/s13256-024-04603-2
pii: 10.1186/s13256-024-04603-2
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
290Informations de copyright
© 2024. The Author(s).
Références
Atabekoglu C, Bozaci E, Tezcan S. Elevated carbohydrate antigen 19–9 in a dermoid cyst. Int J Gynaecol Obstet. 2005;91(3):262–3.
doi: 10.1016/j.ijgo.2005.07.019
pubmed: 16168992
Ahmed A, Lotfollahzadeh S. Cystic teratoma. 2020.
Kim SM, Choi HS, Byun JS, Kim YH, Kim KS, Rim SY, et al. Mucinous adenocarcinoma and strumal carcinoid tumor arising in one mature cystic teratoma of the ovary with synchronous cervical cancer. J Obstetr Gynaecol Res. 2003;29(1):28–32.
doi: 10.1046/j.1341-8076.2003.00073.x
Jafari-Nozad AM, Jahani N, Nazeri N. Squamous cell carcinoma malignant transformation in mature cystic teratoma of the ovary: a case report and review of the literature. J Med Case Rep. 2024;18(1):145.
doi: 10.1186/s13256-024-04465-8
pubmed: 38523295
pmcid: 10962143
Goudeli C, Varytimiadi A, Koufopoulos N, Syrios J, Terzakis E. An ovarian mature cystic teratoma evolving in squamous cell carcinoma: a case report and review of the literature. Gynecol Oncol Rep. 2017;19:27–30.
doi: 10.1016/j.gore.2016.12.005
pubmed: 28050596
Sibarani CNR, Permata HD, Martiana EF, Tjandraprawira KD, Hadinata CV. A rare case of squamous cell carcinoma transformation in a mature cystic teratoma of the ovary. SAGE Open Med Case Rep. 2023;11:2050313X231193305.
doi: 10.1177/2050313X231193305
pubmed: 37581115
pmcid: 10423442
Gadducci A, Guerrieri ME, Cosio S. Squamous cell carcinoma arising from mature cystic teratoma of the ovary: a challenging question for gynecologic oncologists. Crit Rev Oncol Hematol. 2019;133:92–8.
doi: 10.1016/j.critrevonc.2018.10.005
pubmed: 30661663
Avcı S, Selcukbiricik F, Bilici A, Özkan G, Özağarı AA, Borlu F. Squamous cell carcinoma arising in a mature cystic teratoma. Case Rep Obstetr Gynecol. 2012;2012.
Billod JA, Suare J, Natavio KMA. Carcinoid tumor and papillary thyroid carcinoma arising from ovarian mature cystic teratoma: two cases of an extraordinary malignant transformation. Int J Reprod Contracept Obstet Gynecol. 2021;10(4):1686–91.
doi: 10.18203/2320-1770.ijrcog20211159
Kim J-Y. A carcinoid tumor arising from a mature cystic teratoma in a 25-year-old patient: a case study. World J Surg Oncol. 2016;14(1):1–3.
doi: 10.1186/s12957-016-0867-8
Dhal I, Guha P. Primary ovarian carcinoid tumor arising in a case of bilateral mature teratoma: a rare case report. Asian Pacific J Cancer Biol. 2023;8(2):199–202.
Abhilasha N, Bafna U, Pallavi V, Rathod P, Krishnappa S. A review of squamous cell carcinoma arising in mature cystic teratoma of the ovary. Indian J Cancer. 2016;53(4):612–4.
doi: 10.4103/0019-509X.204763
pubmed: 28485364
Hsu W-W, Mao T-L, Chen C-H. Primary ovarian mucinous carcinoid tumor: a case report and review of literature. Taiwan J Obstet Gynecol. 2019;58(4):570–3.
doi: 10.1016/j.tjog.2019.05.025
pubmed: 31307754
Zhai L-R, Zhang X-W, Yu T, Jiang Z-D, Huang D-W, Jia Y, et al. Primary ovarian carcinoid: two cases report and review of literature. Medicine. 2020;99(40): e21109.
doi: 10.1097/MD.0000000000021109
pubmed: 33019380
pmcid: 7535635
Yamasaki T, Yagihashi Y, Shirahase T, Hashimura T, Watanabe C. Primary carcinoid tumor arising in a retroperitoneal mature teratoma in an adult. Int J Urol. 2004;11(10):912–5.
doi: 10.1111/j.1442-2042.2004.00918.x
pubmed: 15479301
Fiore MG, Rossi R, Covelli C, Loizzi V, Piscitelli D, Cormio G. Goblet-cell carcinoid of the ovary: a case report with ultrastructural analysis. J Obstet Gynaecol. 2017;37(2):266–7.
pubmed: 27922277
Robboy SJ, Norris HJ, Scully RE. Insular carcinoid primary in the ovary A clinicopathologic analysis of 48 cases. Cancer. 1975;36(2):404–18.
doi: 10.1002/1097-0142(197508)36:2<404::AID-CNCR2820360216>3.0.CO;2-0
pubmed: 1157010
Li C, Zhang Q, Zhang S, Dong R, Sun C, Qiu C, et al. Squamous cell carcinoma transformation in mature cystic teratoma of the ovary: a systematic review. BMC Cancer. 2019;19(1):1–12.
Tosuner Z, Sönmez FCd, Arici DS, Dansuk R. Carcinoid tumor arising in a mature cystic teratoma: a case report. Oncol Lett. 2015;9(5):2236–8.
doi: 10.3892/ol.2015.2998
pubmed: 26137048
pmcid: 4467324
Orsi NM, Menon M. Primary ovarian neuroendocrine tumor arising in association with a mature cystic teratoma: a case report. Gynecol Oncol Rep. 2016;17:83–5.
doi: 10.1016/j.gore.2016.07.003
pubmed: 27508272
pmcid: 4971231
Petousis S, Kalogiannidis I, Margioula-Siarkou C, Traianos A, Miliaras D, Kamparoudis A, et al. Mature ovarian teratoma with carcinoid tumor in a 28-year-old patient. Case Rep Obstetr Gynecol. 2013;2013.
Ting W, Hsiao S, Lin H, Wei M. Primary carcinoid tumor of the ovary arising in a mature cystic teratoma: a case report. Eur J Gynaec Oncol-ISSN. 2014;35(1):2014.
Zaboli E, Heydari S, Alizadeh-Navaei R. Ovarian squamous cell carcinoma arising from mature cystic teratoma: a case report. Case Rep Clin Pract. 2022;7(4):195–8.