Nocardia
anti-GM-CSF autoantibodies
autoimmune pulmonary alveolar proteinosis
central nervous system infection
nocardiosis
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Jun 2024
Jun 2024
Historique:
received:
30
01
2024
accepted:
05
05
2024
medline:
25
6
2024
pubmed:
25
6
2024
entrez:
25
6
2024
Statut:
epublish
Résumé
Nocardiosis, a bacterial opportunistic infection caused by We performed a prospective, multicenter, nationwide study in France and included patients with a Twenty patients (18 [90%] male) were included, with a median age of 69 (interquartile range, 44-75) years. The organs most frequently involved were the brain (14/20 [70%]) and the lung (12/20 [60%]). Half of the infections were disseminated (10/20 [50%]). Nocardiosis with anti-GM-CSF autoantibodies is associated with a low mortality rate despite a high incidence of brain involvement. Although the occurrence of aPAP was infrequent during the 1-year follow-up period, long-term clinical data are needed to fully understand the potential relationship between nocardiosis, anti-GM-CSF autoantibodies, and aPAP.
Sections du résumé
Background
UNASSIGNED
Nocardiosis, a bacterial opportunistic infection caused by
Methods
UNASSIGNED
We performed a prospective, multicenter, nationwide study in France and included patients with a
Results
UNASSIGNED
Twenty patients (18 [90%] male) were included, with a median age of 69 (interquartile range, 44-75) years. The organs most frequently involved were the brain (14/20 [70%]) and the lung (12/20 [60%]). Half of the infections were disseminated (10/20 [50%]).
Conclusions
UNASSIGNED
Nocardiosis with anti-GM-CSF autoantibodies is associated with a low mortality rate despite a high incidence of brain involvement. Although the occurrence of aPAP was infrequent during the 1-year follow-up period, long-term clinical data are needed to fully understand the potential relationship between nocardiosis, anti-GM-CSF autoantibodies, and aPAP.
Identifiants
pubmed: 38915339
doi: 10.1093/ofid/ofae269
pii: ofae269
pmc: PMC11194753
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofae269Investigateurs
Anne Bergeron-Lafaurie
(A)
Gabrielle Carpentier-Blanc
(G)
Vincent Cottin
(V)
Marie Froidure
(M)
Alice Hadchouel Duverge
(AH)
Stéphane Jouneau
(S)
Frédéric Laurent
(F)
Raphael Lepeule
(R)
Olivier Lortholary
(O)
Matthieu Mahévas
(M)
Cédric Ménard
(C)
Véronica Rodriguez-Nava
(V)
Julie Traclet
(J)
Informations de copyright
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.