Effects of silymarin as adjuvant drug on serum levels of CTRP3, anti-cyclic citrullinated peptide (CCP), and high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis patients.

Anti-CCP CTRP3 Rheumatoid Arthritis Silymarin hs-CRP

Journal

Molecular biology research communications
ISSN: 2345-2005
Titre abrégé: Mol Biol Res Commun
Pays: Iran
ID NLM: 101613459

Informations de publication

Date de publication:
2024
Historique:
medline: 25 6 2024
pubmed: 25 6 2024
entrez: 25 6 2024
Statut: ppublish

Résumé

Silymarin is known for its anti-inflammatory and antioxidant properties. We investigated these effects on serum levels of CTRP3, Anti-CCP, and hs-CRP in individuals with Rheumatoid arthritis (RA). In this study, 42 individuals with RA were recruited and their serum specimens were collected, serum levels of hs-CRP, AntiCCP antibodies, and CTRP3 were measured using ELISA. DNA was extracted and investigated for the existence of possible new mutations in the gene encoding CTRP3 using the PCR technique; the desired fragments were then amplified and sequenced. Another blood sample was collected from the case group after taking

Identifiants

pubmed: 38915456
doi: 10.22099/mbrc.2024.48466.1876
pmc: PMC11194032
doi:

Types de publication

Journal Article

Langues

eng

Pagination

137-145

Déclaration de conflit d'intérêts

The authors declare that they have no conflict of interest.

Auteurs

Mohammad Ehsan Elahi (ME)

Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Daniel Elieh-Ali-Komi (D)

Institute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology and Allergology, Berlin, Germany.

Farjam Goudarzi (F)

Regenerative Medicine Research Center (RMRC), Kermanshah University of Medical Sciences, Iran Medical Sciences.

Ehsan Mohammadi Noori (E)

Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Kermanshah, Iran.

Shirin Assar (S)

Department of Internal Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Mehrdad Shavandi (M)

Student Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Amir Kiani (A)

Regenerative Medicine Research Center (RMRC), Kermanshah University of Medical Sciences, Iran Medical Sciences.
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Kermanshah, Iran.

Homayoin Elahi (H)

Department of Internal Medicine, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Classifications MeSH