Combined coagulation and inflammation markers as predictors of venous thrombo-embolism and death in COVID-19.
ADAMTS13
C-reactive protein
COVID-19
interleukin-6
prognosis
thrombosis
von Willebrand factor
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2024
2024
Historique:
received:
11
03
2024
accepted:
03
05
2024
medline:
25
6
2024
pubmed:
25
6
2024
entrez:
25
6
2024
Statut:
epublish
Résumé
The COVID-19 pandemic related to SARS-CoV-2 virus was responsible for global pandemic. The severe form of the disease was linked to excessive activation of immune pathways together with a systemic cytokine storm response and thrombotic venous or arterial complications. Factors predicting severe outcomes including venous and/or pulmonary thrombosis (VT) and death were identified, but the prognostic role of their combination was not addressed extensively. We investigated the role of prognostic factors from the coagulation or inflammatory pathways to better understand the outcome of the disease. For this, we prospectively studied 167 SARS-CoV-2-positive patients from admission in intensive care units (ICU) or emergency departments from four academic hospitals over a 14-month period. Besides standard biology, we assessed serum concentrations of inflammatory markers, coagulation factors and peripheral blood cells immunophenotyping. Thirty-nine patients (23.3%) developed VT and 30 patients (18%) died. By univariate analysis, C-reactive protein (CRP) level > 150 mg/L, interleukin-6 (IL-6) ≥ 20 pg/mL, D-dimers > 1,500 μg/L, ADAMTS13 activity ≤ 50%, Von. A combination of coagulation and inflammatory markers can refine the prognostication of severe outcome in COVID-19, and could be useful for the initial evaluation of other types of viral infection.
Sections du résumé
Background
UNASSIGNED
The COVID-19 pandemic related to SARS-CoV-2 virus was responsible for global pandemic. The severe form of the disease was linked to excessive activation of immune pathways together with a systemic cytokine storm response and thrombotic venous or arterial complications. Factors predicting severe outcomes including venous and/or pulmonary thrombosis (VT) and death were identified, but the prognostic role of their combination was not addressed extensively.
Objectives
UNASSIGNED
We investigated the role of prognostic factors from the coagulation or inflammatory pathways to better understand the outcome of the disease.
Methods
UNASSIGNED
For this, we prospectively studied 167 SARS-CoV-2-positive patients from admission in intensive care units (ICU) or emergency departments from four academic hospitals over a 14-month period. Besides standard biology, we assessed serum concentrations of inflammatory markers, coagulation factors and peripheral blood cells immunophenotyping.
Results
UNASSIGNED
Thirty-nine patients (23.3%) developed VT and 30 patients (18%) died. By univariate analysis, C-reactive protein (CRP) level > 150 mg/L, interleukin-6 (IL-6) ≥ 20 pg/mL, D-dimers > 1,500 μg/L, ADAMTS13 activity ≤ 50%, Von.
Conclusion
UNASSIGNED
A combination of coagulation and inflammatory markers can refine the prognostication of severe outcome in COVID-19, and could be useful for the initial evaluation of other types of viral infection.
Identifiants
pubmed: 38915768
doi: 10.3389/fmed.2024.1399335
pmc: PMC11194426
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1399335Informations de copyright
Copyright © 2024 Zhu, Bouzid, Travert, Géri, Cohen, Picod, Heming, Rottman, Joly-Laffargue, Veyradier, Capron and Coppo.
Déclaration de conflit d'intérêts
PC was member of the Clinical Advisory Board for Alexion, Sanofi, Takeda, and Janssen. AV had participated to Advisory boards for Sanofi. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.