Recent advances in lycopene and germacrene a biosynthesis and their role as antineoplastic drugs.
Cancer
Germacrene A
Lycopene
Sesquiterpene lactones
Terpenoids
Β-elemene
Journal
World journal of microbiology & biotechnology
ISSN: 1573-0972
Titre abrégé: World J Microbiol Biotechnol
Pays: Germany
ID NLM: 9012472
Informations de publication
Date de publication:
25 Jun 2024
25 Jun 2024
Historique:
received:
26
04
2024
accepted:
17
06
2024
medline:
25
6
2024
pubmed:
25
6
2024
entrez:
25
6
2024
Statut:
epublish
Résumé
Sesquiterpenes and tetraterpenes are classes of plant-derived natural products with antineoplastic effects. While plant extraction of the sesquiterpene, germacrene A, and the tetraterpene, lycopene suffers supply chain deficits and poor yields, chemical synthesis has difficulties in separating stereoisomers. This review highlights cutting-edge developments in producing germacrene A and lycopene from microbial cell factories. We then summarize the antineoplastic properties of β-elemene (a thermal product from germacrene A), sesquiterpene lactones (metabolic products from germacrene A), and lycopene. We also elaborate on strategies to optimize microbial-based germacrene A and lycopene production.
Identifiants
pubmed: 38916754
doi: 10.1007/s11274-024-04057-0
pii: 10.1007/s11274-024-04057-0
doi:
Substances chimiques
Lycopene
SB0N2N0WV6
Sesquiterpenes, Germacrane
0
Antineoplastic Agents
0
Carotenoids
36-88-4
Sesquiterpenes
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
254Subventions
Organisme : National Natural Science Foundation of China
ID : 32200092, 21938004
Organisme : National Key Research and Development Program of China
ID : 2021YFC2100203
Organisme : 111 Project
ID : 111-2-06
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Nature B.V.
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