The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
25 06 2024
Historique:
received: 08 02 2024
accepted: 21 06 2024
medline: 26 6 2024
pubmed: 26 6 2024
entrez: 25 6 2024
Statut: epublish

Résumé

The objective of this study was to investigate the association between a Parkinson's disease (PD)-specific polygenic score (PGS) and protective lifestyle factors on age at onset (AAO) in PD. We included data from 4367 patients with idiopathic PD, 159 patients with GBA1-PD, and 3090 healthy controls of European ancestry from AMP-PD, PPMI, and Fox Insight cohorts. The association between PGS and lifestyle factors on AAO was assessed with linear and Cox proportional hazards models. The PGS showed a negative association with AAO (β = - 1.07, p = 6 × 10

Identifiants

pubmed: 38918550
doi: 10.1038/s41598-024-65640-x
pii: 10.1038/s41598-024-65640-x
doi:

Substances chimiques

Glucosylceramidase EC 3.2.1.45
Aspirin R16CO5Y76E

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

14670

Subventions

Organisme : Michael J. Fox Foundation for Parkinson's Research
ID : MJFF-019271
Organisme : Michael J. Fox Foundation for Parkinson's Research
ID : MJFF-021227
Organisme : Deutsche Forschungsgemeinschaft
ID : FOR2488

Informations de copyright

© 2024. The Author(s).

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Auteurs

Carolin Gabbert (C)

Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.

Leonie Blöbaum (L)

Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.

Theresa Lüth (T)

Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.

Inke R König (IR)

Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany.

Amke Caliebe (A)

Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.

Sebastian Sendel (S)

Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.

Björn-Hergen Laabs (BH)

Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany.

Christine Klein (C)

Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany.

Joanne Trinh (J)

Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany. joanne.trinh@uni-luebeck.de.

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