Localized, highly efficient secretion of signaling proteins by migrasomes.
Journal
Cell research
ISSN: 1748-7838
Titre abrégé: Cell Res
Pays: England
ID NLM: 9425763
Informations de publication
Date de publication:
25 Jun 2024
25 Jun 2024
Historique:
received:
19
01
2024
accepted:
11
06
2024
medline:
26
6
2024
pubmed:
26
6
2024
entrez:
25
6
2024
Statut:
aheadofprint
Résumé
Migrasomes, enriched with signaling molecules such as chemokines, cytokines and angiogenic factors, play a pivotal role in the spatially defined delivery of these molecules, influencing critical physiological processes including organ morphogenesis and angiogenesis. The mechanism governing the accumulation of signaling molecules in migrasomes has been elusive. In this study, we show that secretory proteins, including signaling proteins, are transported into migrasomes by secretory carriers via both the constitutive and regulated secretion pathways. During cell migration, a substantial portion of these carriers is redirected to the rear of the cell and actively transported into migrasomes, driven by the actin-dependent motor protein Myosin-5a. Once at the migrasomes, these carriers fuse with the migrasome membrane through SNARE-mediated mechanisms. Inhibiting migrasome formation significantly reduces secretion, suggesting migrasomes as a principal secretion route in migrating cells. Our findings reveal a specialized, highly localized secretion paradigm in migrating cells, conceptually paralleling the targeted neurotransmitter release observed in neuronal systems.
Identifiants
pubmed: 38918584
doi: 10.1038/s41422-024-00992-7
pii: 10.1038/s41422-024-00992-7
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 92354306
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32330025
Organisme : National Natural Science Foundation of China (National Science Foundation of China)
ID : 32030023
Organisme : Beijing Municipal Science and Technology Commission
ID : Z221100003422012 to L.Y.
Informations de copyright
© 2024. The Author(s).
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