Comparing gene expression profiles of adults with isolated spinal tuberculosis to disseminated spinal tuberculosis identified by
Humans
Tuberculosis, Spinal
/ diagnostic imaging
Positron Emission Tomography Computed Tomography
/ methods
Fluorodeoxyglucose F18
Prospective Studies
Adult
Follow-Up Studies
Cohort Studies
Transcriptome
Time Factors
Treatment Outcome
Male
Radiopharmaceuticals
Gene Expression Profiling
/ methods
Female
Extrapulmonary
Musculoskeletal
Pott`s disease
Spinal
Spondylodiscitis
Tuberculosis
Journal
Journal of orthopaedic surgery and research
ISSN: 1749-799X
Titre abrégé: J Orthop Surg Res
Pays: England
ID NLM: 101265112
Informations de publication
Date de publication:
25 Jun 2024
25 Jun 2024
Historique:
received:
19
04
2024
accepted:
07
06
2024
medline:
26
6
2024
pubmed:
26
6
2024
entrez:
25
6
2024
Statut:
epublish
Résumé
Tuberculosis (TB) is one of the top ten causes of death worldwide, with approximately 10 million cases annually. Focus has been on pulmonary TB, while extrapulmonary TB (EPTB) has received little attention. Diagnosis of EPTB remains challenging due to the invasive procedures required for sample collection. Spinal TB (STB) accounts for 10% of EPTB and often leads to lifelong debilitating disease due to devastating spinal deformation and compression of neural structures. Little is known about the extent of disease, although both isolated STB and a disseminated form of STB have been described. In our Spinal TB X cohort study, we aim to describe the clinical phenotype of STB using whole-body A single-centre, prospective cohort study will be established to describe the distributional pattern of STB detected by whole-body The Spinal TB X cohort study is the first prospective cohort study using whole-body 18FDG-PET/CT scans in patients with microbiologically confirmed spinal tuberculosis. Dual imaging techniques of the spine using The study has been registered on ClinicalTrials.gov (NCT05610098).
Sections du résumé
BACKGROUND
BACKGROUND
Tuberculosis (TB) is one of the top ten causes of death worldwide, with approximately 10 million cases annually. Focus has been on pulmonary TB, while extrapulmonary TB (EPTB) has received little attention. Diagnosis of EPTB remains challenging due to the invasive procedures required for sample collection. Spinal TB (STB) accounts for 10% of EPTB and often leads to lifelong debilitating disease due to devastating spinal deformation and compression of neural structures. Little is known about the extent of disease, although both isolated STB and a disseminated form of STB have been described. In our Spinal TB X cohort study, we aim to describe the clinical phenotype of STB using whole-body
METHODS
METHODS
A single-centre, prospective cohort study will be established to describe the distributional pattern of STB detected by whole-body
DISCUSSION
CONCLUSIONS
The Spinal TB X cohort study is the first prospective cohort study using whole-body 18FDG-PET/CT scans in patients with microbiologically confirmed spinal tuberculosis. Dual imaging techniques of the spine using
TRIAL REGISTRATION
BACKGROUND
The study has been registered on ClinicalTrials.gov (NCT05610098).
Identifiants
pubmed: 38918806
doi: 10.1186/s13018-024-04840-7
pii: 10.1186/s13018-024-04840-7
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Radiopharmaceuticals
0
Banques de données
ClinicalTrials.gov
['NCT05610098']
Types de publication
Journal Article
Comparative Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
376Subventions
Organisme : AO Spine
ID : AOS-DIA-22-029-TRA
Organisme : EDCTP2, European Union
ID : RIA2017T- 2004-StatinTB
Organisme : EDCTP2, European Union
ID : RIA2017T- 2004-StatinTB
Organisme : EDCTP2, European Union
ID : RIA2017T- 2004-StatinTB
Organisme : EDCTP2, European Union
ID : RIA2017T- 2004-StatinTB
Informations de copyright
© 2024. The Author(s).
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