Magnetic Particle Imaging-Guided Thermal Simulations for Magnetic Particle Hyperthermia.

finite element analysis image guidance magnetic hyperthermia magnetic nanoparticles magnetic particle imaging

Journal

Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216

Informations de publication

Date de publication:
20 Jun 2024
Historique:
received: 20 04 2024
revised: 13 06 2024
accepted: 17 06 2024
medline: 26 6 2024
pubmed: 26 6 2024
entrez: 26 6 2024
Statut: epublish

Résumé

Magnetic particle hyperthermia (MPH) enables the direct heating of solid tumors with alternating magnetic fields (AMFs). One challenge with MPH is the unknown particle distribution in tissue after injection. Magnetic particle imaging (MPI) can measure the nanoparticle content and distribution in tissue after delivery. The objective of this study was to develop a clinically translatable protocol that incorporates MPI data into finite element calculations for simulating tissue temperatures during MPH. To verify the protocol, we conducted MPH experiments in tumor-bearing mouse cadavers. Five 8-10-week-old female BALB/c mice bearing subcutaneous 4T1 tumors were anesthetized and received intratumor injections of Synomag

Identifiants

pubmed: 38921935
pii: nano14121059
doi: 10.3390/nano14121059
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : R01 CA257557
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA247290
Pays : United States
Organisme : NIH HHS
ID : S10 OD026740
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA006973
Pays : United States
Organisme : NIH HHS
ID : R37 CA229417
Pays : United States
Organisme : NCI NIH HHS
ID : R44 CA285064
Pays : United States

Auteurs

Hayden Carlton (H)

Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Nageshwar Arepally (N)

Department of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA 17057, USA.

Sean Healy (S)

Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Anirudh Sharma (A)

Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Sarah Ptashnik (S)

Materialise NV, 3001 Leuven, Belgium.

Maureen Schickel (M)

Materialise NV, 3001 Leuven, Belgium.

Matt Newgren (M)

Magnetic Insight Inc., Alameda, CA 94502, USA.

Patrick Goodwill (P)

Magnetic Insight Inc., Alameda, CA 94502, USA.

Anilchandra Attaluri (A)

Department of Mechanical Engineering, School of Science, Engineering, and Technology, The Pennsylvania State University-Harrisburg, Middletown, PA 17057, USA.

Robert Ivkov (R)

Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Department of Oncology, Sydney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
Department of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Department of Materials Science and Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

Classifications MeSH