Lysophosphatidic Acid Stimulates Mitogenic Activity and Signaling in Human Neuroblastoma Cells through a Crosstalk with Anaplastic Lymphoma Kinase.
Humans
Lysophospholipids
/ metabolism
Anaplastic Lymphoma Kinase
/ metabolism
Neuroblastoma
/ metabolism
Cell Proliferation
/ drug effects
Cell Line, Tumor
Signal Transduction
/ drug effects
Phosphorylation
/ drug effects
Piperidines
/ pharmacology
Carbazoles
/ pharmacology
Forkhead Box Protein O3
/ metabolism
Mitogen-Activated Protein Kinase 3
/ metabolism
MAP Kinase Signaling System
/ drug effects
FoxO3a
anaplastic lymphoma kinase
cell proliferation
extracellular signal-regulated kinases 1 and 2
human neuroblastoma cells
lysophosphatidic acid
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
28 May 2024
28 May 2024
Historique:
received:
26
03
2024
revised:
21
05
2024
accepted:
24
05
2024
medline:
27
6
2024
pubmed:
27
6
2024
entrez:
27
6
2024
Statut:
epublish
Résumé
Lysophosphatidic acid (LPA) is a well-documented pro-oncogenic factor in different cancers, but relatively little is known on its biological activity in neuroblastoma. The LPA effects and the participation of the tyrosine kinase receptor anaplastic lymphoma kinase (ALK) in LPA mitogenic signaling were studied in human neuroblastoma cell lines. We used light microscopy and [
Identifiants
pubmed: 38927035
pii: biom14060631
doi: 10.3390/biom14060631
pii:
doi:
Substances chimiques
Lysophospholipids
0
lysophosphatidic acid
PG6M3969SG
Anaplastic Lymphoma Kinase
EC 2.7.10.1
ALK protein, human
EC 2.7.10.1
Piperidines
0
Carbazoles
0
Forkhead Box Protein O3
0
alectinib
LIJ4CT1Z3Y
FOXO3 protein, human
0
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Sardegna Ricerche (Italy)
ID : Progetto IBERNAT-NBL -POR Sardegna 2014-2020 CUP F21B17000730005