Insights into the Effects of Ligand Binding on Leucyl-tRNA Synthetase Inhibitors for Tuberculosis: In Silico Analysis and Isothermal Titration Calorimetry Validation.

Mycobacterium tuberculosis / enzymology Ligands Antitubercular Agents / pharmacology Leucine-tRNA Ligase / antagonists & inhibitors Molecular Docking Simulation Enzyme Inhibitors / pharmacology Calorimetry Molecular Dynamics Simulation Tuberculosis / drug therapy Computer Simulation Protein Binding Humans
computer-aided drug design leucyl t-RNA synthetase inhibition molecular dynamics simulation virtual screening

Journal

Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414

Informations de publication

Date de publication:
16 Jun 2024
Historique:
received: 27 04 2024
revised: 09 06 2024
accepted: 12 06 2024
medline: 27 6 2024
pubmed: 27 6 2024
entrez: 27 6 2024
Statut: epublish

Résumé

Incidences of drug-resistant tuberculosis have become common and are rising at an alarming rate. Aminoacyl t-RNA synthetase has been validated as a newer target against

Identifiants

DOI: 10.3390/biom14060711 PMID: 38927114
pubmed: 38927114
pii: biom14060711
doi: 10.3390/biom14060711
pii:
doi:

Substances chimiques

Ligands 0
Antitubercular Agents 0
Leucine-tRNA Ligase EC 6.1.1.4
Enzyme Inhibitors 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deanship for Research and Innovation, Ministry of Education Saudi Arabia
ID : ISP22-16

Auteurs

Zia Ur Rehman (ZU)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jazan University, P.O. Box 114, Jazan 45142, Saudi Arabia.
ORCID: 0000-0002-6540-7966

Asim Najmi (A)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jazan University, P.O. Box 114, Jazan 45142, Saudi Arabia.
ORCID: 0000-0002-7529-5523

Khalid Zoghebi (K)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jazan University, P.O. Box 114, Jazan 45142, Saudi Arabia.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › Insights into the Effects of Ligand Binding on...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Insights into the Effects of Ligand Binding on...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antituberculeux › Insights into the Effects of Ligand Binding on...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Carbon-oxygen ligases › Amino acyl-tRNA synthetases › Leucine-tRNA ligase › Insights into the Effects of Ligand Binding on...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Insights into the Effects of Ligand Binding on...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Insights into the Effects of Ligand Binding on...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Calorimétrie › Insights into the Effects of Ligand Binding on...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Insights into the Effects of Ligand Binding on...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Insights into the Effects of Ligand Binding on...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Insights into the Effects of Ligand Binding on...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Insights into the Effects of Ligand Binding on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Insights into the Effects of Ligand Binding on...