Disrupted Endoplasmic Reticulum Ca
Ca2+ handling
ER stress
chaperone
diabetes
inositol trisphosphate receptor
insulin
islet
ryanodine receptor
unfolded protein response
β-cell
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
25 May 2024
25 May 2024
Historique:
received:
03
04
2024
revised:
17
05
2024
accepted:
17
05
2024
medline:
27
6
2024
pubmed:
27
6
2024
entrez:
27
6
2024
Statut:
epublish
Résumé
The β-cell workload increases in the setting of insulin resistance and reduced β-cell mass, which occurs in type 2 and type 1 diabetes, respectively. The prolonged elevation of insulin production and secretion during the pathogenesis of diabetes results in β-cell ER stress. The depletion of β-cell Ca
Identifiants
pubmed: 38927260
pii: biology13060379
doi: 10.3390/biology13060379
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NIH HHS
ID : 1R01DK129340-23S1
Pays : United States
Organisme : NIH HHS
ID : 1R01DK129340-23A1
Pays : United States
Organisme : NIH HHS
ID : 1R01DK136768-23A1
Pays : United States