The Effect of Targeted Hyperoxemia on Brain Immunohistochemistry after Long-Term, Resuscitated Porcine Acute Subdural Hematoma and Hemorrhagic Shock.

Animals Swine Hematoma, Subdural, Acute / metabolism Shock, Hemorrhagic / metabolism Brain / metabolism Blood-Brain Barrier / metabolism Immunohistochemistry Oxidative Stress Resuscitation / methods Disease Models, Animal Oxygen / metabolism Tyrosine / analogs & derivatives
blood–brain barrier cystathionine-β-synthase cystathionine-γ-lyase oxidative/nitrosative stress oxytocin oxytocin receptor traumatic brain injury

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
14 Jun 2024
Historique:
received: 07 05 2024
revised: 06 06 2024
accepted: 11 06 2024
medline: 27 6 2024
pubmed: 27 6 2024
entrez: 27 6 2024
Statut: epublish

Résumé

Epidemiological data suggest that moderate hyperoxemia may be associated with an improved outcome after traumatic brain injury. In a prospective, randomized investigation of long-term, resuscitated acute subdural hematoma plus hemorrhagic shock (ASDH + HS) in 14 adult, human-sized pigs, targeted hyperoxemia (200 < P

Identifiants

DOI: 10.3390/ijms25126574 PMID: 38928283
pubmed: 38928283
pii: ijms25126574
doi: 10.3390/ijms25126574
pii:
doi:

Substances chimiques

3-nitrotyrosine 3604-79-3
Oxygen S88TT14065
Tyrosine 42HK56048U

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : 251293561
Organisme : Deutsche Forschungsgemeinschaft
ID : 465409392

Auteurs

Franziska Münz (F)

Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.
Department of Anesthesiology and Intensive Care Medicine, University Hospital Ulm, 89081 Ulm, Germany.

Thomas Datzmann (T)

Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.

Andrea Hoffmann (A)

Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.

Michael Gröger (M)

Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.

René Mathieu (R)

Department of Neurosurgery, German Federal Armed Forces Hospital Ulm, 89081 Ulm, Germany.

Simon Mayer (S)

Department of Neurosurgery, German Federal Armed Forces Hospital Ulm, 89081 Ulm, Germany.

Fabian Zink (F)

Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.
ORCID: 0000-0001-9458-741X

Holger Gässler (H)

Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy, German Armed Forces Hospital Ulm, 89081 Ulm, Germany.
ORCID: 0000-0001-5610-3197

Eva-Maria Wolfschmitt (EM)

Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.

Melanie Hogg (M)

Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.

Enrico Calzia (E)

Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.
ORCID: 0000-0003-2663-9147

Pierre Asfar (P)

Department of Intensive Care and Hyperbaric Medicine, University Hospital Angers, 49045 Angers, France.

Peter Radermacher (P)

Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.

Thomas Kapapa (T)

Department of Neurosurgery, University Hospital Ulm, 89081 Ulm, Germany.
ORCID: 0000-0003-1237-5347

Tamara Merz (T)

Institute for Anesthesiological Pathophysiology and Process Engineering, Ulm University, 89081 Ulm, Germany.
Department of Anesthesiology and Intensive Care Medicine, University Hospital Ulm, 89081 Ulm, Germany.
ORCID: 0000-0002-5519-9171

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The Effect of Targeted Hyperoxemia on Brain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Suidae › The Effect of Targeted Hyperoxemia on Brain...
questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Hémorragie intracrânienne traumatique › Hématome subdural › Hématome subdural aigu › The Effect of Targeted Hyperoxemia on Brain...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Choc › Choc hémorragique › The Effect of Targeted Hyperoxemia on Brain...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › The Effect of Targeted Hyperoxemia on Brain...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › The Effect of Targeted Hyperoxemia on Brain...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Immunohistochimie › The Effect of Targeted Hyperoxemia on Brain...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › The Effect of Targeted Hyperoxemia on Brain...
questionsmedicales.fr › Thérapeutique › Traitement d'urgence › Réanimation › The Effect of Targeted Hyperoxemia on Brain...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › The Effect of Targeted Hyperoxemia on Brain...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › The Effect of Targeted Hyperoxemia on Brain...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Acides aminés aromatiques › Tyrosine › The Effect of Targeted Hyperoxemia on Brain...