Mts1 (S100A4) and Its Peptide Demonstrate Cytotoxic Activity in Complex with Tag7 (PGLYRP1) Peptide.

Humans Receptors, Tumor Necrosis Factor, Type I / metabolism Apoptosis / drug effects Protein Binding Molecular Docking Simulation Cell Line, Tumor Peptides / chemistry Molecular Dynamics Simulation Signal Transduction / drug effects Necroptosis / drug effects Oligopeptides / chemistry Cytokines
PGLYRP1 S100A4 TNFR1 apoptosis cytotoxicity molecular docking necroptosis short peptides thermophoresis tumor cells

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
16 Jun 2024
Historique:
received: 15 05 2024
revised: 07 06 2024
accepted: 13 06 2024
medline: 27 6 2024
pubmed: 27 6 2024
entrez: 27 6 2024
Statut: epublish

Résumé

Receptors of cytokines are major regulators of the immune response. In this work, we have discovered two new ligands that can activate the TNFR1 (tumor necrosis factor receptor 1) receptor. Earlier, we found that the peptide of the Tag (PGLYRP1) protein designated 17.1 can interact with the TNFR1 receptor. Here, we have found that the Mts1 (S100A4) protein interacts with this peptide with a high affinity (K

Identifiants

DOI: 10.3390/ijms25126633 PMID: 38928339
pubmed: 38928339
pii: ijms25126633
doi: 10.3390/ijms25126633
pii:
doi:

Substances chimiques

Receptors, Tumor Necrosis Factor, Type I 0
PGLYRP1 protein, human 0
Peptides 0
Oligopeptides 0
Cytokines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Russian Science Foundation
ID : 23-14-00076

Auteurs

Daria M Yurkina (DM)

Institute of Gene Biology (RAS), Moscow 119334, Russia.
ORCID: 0009-0003-8367-5133

Elena A Romanova (EA)

Institute of Gene Biology (RAS), Moscow 119334, Russia.

Kirill A Shcherbakov (KA)

Institute of Biomedical Chemistry, Pogodinskaya Street 10, Moscow 119121, Russia.

Rustam H Ziganshin (RH)

Shemyakin & Ovchinnikov Institute of Bioorganic, Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya, 16/10, Moscow 117997, Russia.

Denis V Yashin (DV)

Institute of Gene Biology (RAS), Moscow 119334, Russia.

Lidia P Sashchenko (LP)

Institute of Gene Biology (RAS), Moscow 119334, Russia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mts1 (S100A4) and Its Peptide Demonstrate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux facteurs de nécrose tumorale › Récepteur au facteur de nécrose tumorale de type I › Mts1 (S100A4) and Its Peptide Demonstrate...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Mts1 (S100A4) and Its Peptide Demonstrate...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › Mts1 (S100A4) and Its Peptide Demonstrate...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Mts1 (S100A4) and Its Peptide Demonstrate...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Mts1 (S100A4) and Its Peptide Demonstrate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Mts1 (S100A4) and Its Peptide Demonstrate...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de dynamique moléculaire › Mts1 (S100A4) and Its Peptide Demonstrate...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Mts1 (S100A4) and Its Peptide Demonstrate...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Nécroptose › Mts1 (S100A4) and Its Peptide Demonstrate...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Mts1 (S100A4) and Its Peptide Demonstrate...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Mts1 (S100A4) and Its Peptide Demonstrate...