Selected microRNA Expression and Protein Regulator Secretion by Adipose Tissue-Derived Mesenchymal Stem Cells and Metabolic Syndrome.
Humans
MicroRNAs
/ genetics
Female
Male
Metabolic Syndrome
/ metabolism
Mesenchymal Stem Cells
/ metabolism
Adult
Middle Aged
Adipose Tissue
/ metabolism
Insulin-Like Growth Factor I
/ metabolism
Obesity
/ metabolism
Interleukin-10
/ metabolism
Gene Expression Regulation
Vascular Endothelial Growth Factor A
/ metabolism
IGF-1
IL-10
adipose tissue
cholesterol
mesenchymal stem cells
mesenchymal stromal cells
metabolic syndrome
miR-155
microRNA
obesity
stem cells
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Jun 2024
17 Jun 2024
Historique:
received:
02
05
2024
revised:
12
06
2024
accepted:
13
06
2024
medline:
27
6
2024
pubmed:
27
6
2024
entrez:
27
6
2024
Statut:
epublish
Résumé
The role of adipose mesenchymal stem cells (Ad-MSCs) in metabolic syndrome remains unclear. We aimed to assess the expression of selected microRNAs in Ad-MSCs of non-diabetic adults in relation to Ad-MSC secretion of protein regulators and basic metabolic parameters. Ten obese, eight overweight, and five normal weight subjects were enrolled: 19 females and 4 males; aged 43.0 ± 8.9 years. Ad-MSCs were harvested from abdominal subcutaneous fat. Ad-MSC cellular expressions of four microRNAs (2
Identifiants
pubmed: 38928349
pii: ijms25126644
doi: 10.3390/ijms25126644
pii:
doi:
Substances chimiques
MicroRNAs
0
Insulin-Like Growth Factor I
67763-96-6
Interleukin-10
130068-27-8
Vascular Endothelial Growth Factor A
0
MIRN155 microRNA, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical University of Silesia
ID : KNW-1-178/N/7/K, KNW-1-008/K/8/K, KNW-1-146/K/9/K and PCN-1-193/K/2/0