Discovery of Di(het)arylmethane and Dibenzoxanthene Derivatives as Potential Anticancer Agents.

Humans Antineoplastic Agents / pharmacology Apoptosis / drug effects Cell Line, Tumor Methane / analogs & derivatives Cell Proliferation / drug effects Xanthenes / pharmacology
anticancer agents cytotoxic activity di(het)arylmethane dibenzoxanthene

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
18 Jun 2024
Historique:
received: 14 05 2024
revised: 06 06 2024
accepted: 10 06 2024
medline: 27 6 2024
pubmed: 27 6 2024
entrez: 27 6 2024
Statut: epublish

Résumé

A family of bifunctional dihetarylmethanes and dibenzoxanthenes is assembled via a reaction of acetals containing a 2-chloroacetamide moiety with phenols and related oxygen-containing heterocycles. These compounds demonstrated selective antitumor activity associated with the induction of cell apoptosis and inhibition of the process of glycolysis. In particular, bis(heteroaryl)methane containing two 4-hydroxy-6-methyl-2

Identifiants

DOI: 10.3390/ijms25126724 PMID: 38928428
pubmed: 38928428
pii: ijms25126724
doi: 10.3390/ijms25126724
pii:
doi:

Substances chimiques

Antineoplastic Agents 0
Methane OP0UW79H66
Xanthenes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Andrey Smolobochkin (A)

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan 420088, Russia.
ORCID: 0000-0002-1470-8136

Dinara Niyazova (D)

Laboratory of Engineering Profile, Department of Engineering Technology, Korkyt Ata Kyzylorda University, Ayteke bi Str., 29A, Kyzylorda 120014, Kazakhstan.

Almir Gazizov (A)

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan 420088, Russia.
ORCID: 0000-0001-9899-9606

Marat Syzdykbayev (M)

Laboratory of Engineering Profile, Department of Engineering Technology, Korkyt Ata Kyzylorda University, Ayteke bi Str., 29A, Kyzylorda 120014, Kazakhstan.
Nazarbayev Intellectual School Chemical-Biological Direction in Kyzylorda, Sultan Beybars Str., 6, Kyzylorda 120014, Kazakhstan.

Alexandra Voloshina (A)

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan 420088, Russia.
ORCID: 0000-0002-3540-8554

Syumbelya Amerhanova (S)

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan 420088, Russia.

Anna Lyubina (A)

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan 420088, Russia.
ORCID: 0000-0002-2816-8142

Margarita Neganova (M)

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan 420088, Russia.
Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Severnij pr., 1, Chernogolovka 142432, Russia.
ORCID: 0000-0001-9346-5920

Yulia Aleksandrova (Y)

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan 420088, Russia.
Institute of Physiologically Active Compounds at Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Severnij pr., 1, Chernogolovka 142432, Russia.
ORCID: 0000-0002-5370-3370

Olga Babaeva (O)

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan 420088, Russia.

Julia Voronina (J)

N.S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii pr., 31, Moscow 119071, Russia.
ORCID: 0000-0001-9222-5853

Nurbol Appazov (N)

Laboratory of Engineering Profile, Department of Engineering Technology, Korkyt Ata Kyzylorda University, Ayteke bi Str., 29A, Kyzylorda 120014, Kazakhstan.
Limited Liability Partnership «DPS-Kyzylorda», Amangeldi Str., 112A, Kyzylorda 120014, Kazakhstan.

Oleg Sinyashin (O)

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan 420088, Russia.

Igor Alabugin (I)

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan 420088, Russia.
Department of Chemistry and Biochemistry, Florida State University, Chieftan Way Str., 95, Tallahassee, FL 32306-3290, USA.
ORCID: 0000-0001-9289-3819

Alexander Burilov (A)

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan 420088, Russia.

Michail Pudovik (M)

Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Str., 8, Kazan 420088, Russia.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discovery of Di(het)arylmethane and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Discovery of Di(het)arylmethane and...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Discovery of Di(het)arylmethane and...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Discovery of Di(het)arylmethane and...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcanes › Méthane › Discovery of Di(het)arylmethane and...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Discovery of Di(het)arylmethane and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Xanthènes › Discovery of Di(het)arylmethane and...