Unique Splicing of

Animals Low Density Lipoprotein Receptor-Related Protein-5 / genetics Brain / metabolism Mice Alternative Splicing Mice, Knockout Liver / metabolism Mice, Inbred C57BL
LRP5 RNA-seq brain liver retinoic acid synapse transcriptome

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
20 Jun 2024
Historique:
received: 16 05 2024
revised: 11 06 2024
accepted: 13 06 2024
medline: 27 6 2024
pubmed: 27 6 2024
entrez: 27 6 2024
Statut: epublish

Résumé

Low-density lipoprotein receptor-related protein 5 (LRP5) is a constitutively expressed receptor with observed roles in bone homeostasis, retinal development, and cardiac metabolism. However, the function of LRP5 in the brain remains unexplored. This study investigates LRP5's role in the central nervous system by conducting an extensive analysis using RNA-seq tools and in silico assessments. Two protein-coding

Identifiants

DOI: 10.3390/ijms25126763 PMID: 38928468
pubmed: 38928468
pii: ijms25126763
doi: 10.3390/ijms25126763
pii:
doi:

Substances chimiques

Low Density Lipoprotein Receptor-Related Protein-5 0
Lrp5 protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Spanish Ministry of Economy and Competitiveness of Science "Agencia Estatal de Investigación"
ID : AEI/10.13039/501100011033-[PID2019-107160RB-I00]
Organisme : FEDER "Una Manera de Hacer Europa"
ID : PMP22/00108
Organisme : Instituto de Salud Carlos III
ID : CB16/11/00411
Organisme : Instituto de Salud Carlos III
ID : PI23-00589
Organisme : Red RICORS TERAV
ID : RD21/0017/0013
Organisme : La Marato de TV3
ID : 202304-10

Auteurs

Aureli Luquero (A)

Cardiovascular Program, Institut de Recerca de Sant Pau, 08025 Barcelona, Spain.
Biomedicine Doctorate Program, Universitat de Barcelona, 08007 Barcelona, Spain.

Noelia Pimentel (N)

Cardiovascular Program, Institut de Recerca de Sant Pau, 08025 Barcelona, Spain.
Biomedicine Doctorate Program, Universitat de Barcelona, 08007 Barcelona, Spain.

Gemma Vilahur (G)

Cardiovascular Program, Institut de Recerca de Sant Pau, 08025 Barcelona, Spain.
Centro Investigación Biomédica en Red-Cardiovascular (CIBER-CV), Instituto de Salud Carlos III, 28029 Madrid, Spain.

Lina Badimon (L)

Cardiovascular Program, Institut de Recerca de Sant Pau, 08025 Barcelona, Spain.
Centro Investigación Biomédica en Red-Cardiovascular (CIBER-CV), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Universitat Autònoma de Barcelona, 08193 Barcelona, Spain.
ORCID: 0000-0002-9162-2459

Maria Borrell-Pages (M)

Cardiovascular Program, Institut de Recerca de Sant Pau, 08025 Barcelona, Spain.
Centro Investigación Biomédica en Red-Cardiovascular (CIBER-CV), Instituto de Salud Carlos III, 28029 Madrid, Spain.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Unique Splicing of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs Wnt › Protéine-5 apparentée au récepteur des LDL › Unique Splicing of
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Unique Splicing of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Unique Splicing of
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Épissage des ARN › Épissage alternatif › Unique Splicing of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Unique Splicing of
questionsmedicales.fr › Système digestif › Foie › Unique Splicing of
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Unique Splicing of