Stroke Caused by Vasculitis Induced by Periodontitis-Associated Oral Bacteria after Wisdom Teeth Extraction.

Porphyromonas gingivalis bacteremia interkingdom signaling ischemic stroke meningitis periodontitis quorum sensing vasculitis

Journal

Brain sciences
ISSN: 2076-3425
Titre abrégé: Brain Sci
Pays: Switzerland
ID NLM: 101598646

Informations de publication

Date de publication:
28 May 2024
Historique:
received: 15 05 2024
revised: 26 05 2024
accepted: 27 05 2024
medline: 27 6 2024
pubmed: 27 6 2024
entrez: 27 6 2024
Statut: epublish

Résumé

Invasive dental procedures, such as wisdom teeth removal, have been identified as potential triggers for vascular events due to the entry of oral bacteria into the bloodstream, leading to acute vascular inflammation and endothelial dysfunction. This study presents the case of a 27-year-old healthy male who developed ischemic stroke resulting from bacteremia after undergoing wisdom teeth extraction. Initially, the patient experienced fever and malaise, which were followed by right-sided hemiplegia. Diagnostic imaging, including a CT scan, identified a subacute infarction in the posterior crus of the left internal capsule, and MRI findings indicated inflammatory changes in the masticatory muscles. Further investigations involving biopsies of the masticatory muscles, along with blood and cerebrospinal fluid samples, confirmed bacterial meningitis with associated vasculitis. Notably, oral bacteria linked to periodontitis, including

Identifiants

pubmed: 38928550
pii: brainsci14060550
doi: 10.3390/brainsci14060550
pii:
doi:

Types de publication

Case Reports Journal Article

Langues

eng

Auteurs

David Kiramira (D)

Department of Periodontology and Operative Dentistry, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

Timo Uphaus (T)

Department of Neurology and Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

Ahmed Othman (A)

Department of Neuroradiology, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

Ralf Heermann (R)

Institute of Molecular Physiology, Microbiology and Biotechnology, Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Institute for Biotechnology and Drug Research gGmbH (ibwf), 55128 Mainz, Germany.

James Deschner (J)

Department of Periodontology and Operative Dentistry, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

Lena Katharina Müller-Heupt (LK)

Department of Periodontology and Operative Dentistry, University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

Classifications MeSH