Human Leukocyte Antigen-Allelic Variations May Influence the Age at Cancer Diagnosis in Lynch Syndrome.

Lynch syndrome age at cancer diagnosis cancer risk genetic risk modifiers germline pathogenic variant MLH1:c.1528C > T human leukocyte antigen (HLA) personalized cancer screening

Journal

Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269

Informations de publication

Date de publication:
27 May 2024
Historique:
received: 10 05 2024
revised: 22 05 2024
accepted: 24 05 2024
medline: 27 6 2024
pubmed: 27 6 2024
entrez: 27 6 2024
Statut: epublish

Résumé

Lynch syndrome (LS) is an inherited cancer predisposition disorder associated with an elevated risk of developing various solid cancers, but mostly colorectal cancer (CRC). Despite having the same germline pathogenic variant (PV) in one of the mis-match repair genes or the

Identifiants

DOI: 10.3390/jpm14060575 PMID: 38929796
pubmed: 38929796
pii: jpm14060575
doi: 10.3390/jpm14060575
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : South African Medical Research Council
ID : SAMRC-ISP

Auteurs

Lutricia Ndou (L)

UCT/MRC Genomic and Precision Medicine Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, The University of Cape Town, Affiliated Hospitals, Cape Town 7704, South Africa.
ORCID: 0000-0002-7203-7780

Ramadhani Chambuso (R)

UCT/MRC Genomic and Precision Medicine Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, The University of Cape Town, Affiliated Hospitals, Cape Town 7704, South Africa.
ORCID: 0000-0001-8794-604X

Ziyaad Valley-Omar (Z)

Medical Virology, National Health Laboratory Service, Groote Schuur Hospital, The University of Cape Town, Cape Town 7925, South Africa.
ORCID: 0000-0003-4804-3774

George Rebello (G)

UCT/MRC Genomic and Precision Medicine Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, The University of Cape Town, Affiliated Hospitals, Cape Town 7704, South Africa.

Ursula Algar (U)

The Colorectal Unit of the Department of Surgery, Groote Schuur Hospital, The University of Cape Town, Cape Town 7925, South Africa.

Paul Goldberg (P)

The Colorectal Unit of the Department of Surgery, Groote Schuur Hospital, The University of Cape Town, Cape Town 7925, South Africa.
ORCID: 0000-0003-1612-7519

Adam Boutall (A)

The Colorectal Unit of the Department of Surgery, Groote Schuur Hospital, The University of Cape Town, Cape Town 7925, South Africa.

Raj Ramesar (R)

UCT/MRC Genomic and Precision Medicine Research Unit, Division of Human Genetics, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, The University of Cape Town, Affiliated Hospitals, Cape Town 7704, South Africa.
ORCID: 0000-0001-5688-1634

Classifications MeSH