Investigation of the Efficacy of Benzylidene-3-methyl-2-thioxothiazolidin-4-one Analogs with Antioxidant Activities on the Inhibition of Mushroom and Mammal Tyrosinases.
Monophenol Monooxygenase
/ antagonists & inhibitors
Agaricales
/ enzymology
Animals
Antioxidants
/ pharmacology
Mice
Enzyme Inhibitors
/ pharmacology
Molecular Docking Simulation
Melanins
/ antagonists & inhibitors
Thiazolidines
/ chemistry
Cell Line, Tumor
Kinetics
Melanoma, Experimental
/ drug therapy
Benzylidene Compounds
/ pharmacology
Pyrones
BMTTZD
docking simulation
melanin
tyrosinase
β-phenyl-α,β-unsaturated carbonyl
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
18 Jun 2024
18 Jun 2024
Historique:
received:
24
04
2024
revised:
10
05
2024
accepted:
13
06
2024
medline:
27
6
2024
pubmed:
27
6
2024
entrez:
27
6
2024
Statut:
epublish
Résumé
Based on the fact that substances with a β-phenyl-α,β-unsaturated carbonyl (PUSC) motif confer strong tyrosinase inhibitory activity, benzylidene-3-methyl-2-thioxothiazolidin-4-one (BMTTZD) analogs
Identifiants
pubmed: 38930952
pii: molecules29122887
doi: 10.3390/molecules29122887
pii:
doi:
Substances chimiques
Monophenol Monooxygenase
EC 1.14.18.1
Antioxidants
0
Enzyme Inhibitors
0
Melanins
0
Thiazolidines
0
kojic acid
6K23F1TT52
Benzylidene Compounds
0
Pyrones
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea (NRF) grant funded by the Korean government (MIST)
ID : NRF-2020R1A2C1004198
Organisme : Basic Science Research Program Through the National Research Foundation (NRF) of Korea funded the Ministry of Education
ID : NRF-2021R1I1A1A01052284