Focused Ultrasound-Mediated Disruption of the Blood-Brain Barrier for AAV9 Delivery in a Mouse Model of Huntington's Disease.

Huntington’s disease blood–brain barrier opening focused ultrasound gene therapy microbubbles

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
24 May 2024
Historique:
received: 19 04 2024
revised: 17 05 2024
accepted: 20 05 2024
medline: 27 6 2024
pubmed: 27 6 2024
entrez: 27 6 2024
Statut: epublish

Résumé

Huntington's disease (HD) is a monogenic neurodegenerative disorder caused by a cytosine-adenine-guanine (CAG) trinucleotide repeat expansion in the

Identifiants

pubmed: 38931834
pii: pharmaceutics16060710
doi: 10.3390/pharmaceutics16060710
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIH HHS
ID : R01NS123557
Pays : United States
Organisme : Brigham Research Institute
ID : N/A
Organisme : Hereditary Disease Foundation
ID : N/A

Auteurs

Bernie S Owusu-Yaw (BS)

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Yongzhi Zhang (Y)

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Lilyan Garrett (L)

College of Science, Northeastern University, Boston, MA 02115, USA.

Alvin Yao (A)

Department of Engineering, Harvard University, Cambridge, MA 02138, USA.

Kai Shing (K)

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

Ana Rita Batista (AR)

Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.

Miguel Sena-Esteves (M)

Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA 01655, USA.

Jaymin Upadhyay (J)

Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Kimberly Kegel-Gleason (K)

Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

Nick Todd (N)

Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Classifications MeSH