Development of Clarstatin, a Novel Drug Lead for the Therapy of Autoimmune Uveitis.

backbone cyclization calreticulin experimental autoimmune uveoretinitis inflammatory autoimmune diseases peptidomimetic peptomer thiourea-bridged uveitis

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
27 May 2024
Historique:
received: 09 05 2024
revised: 21 05 2024
accepted: 23 05 2024
medline: 27 6 2024
pubmed: 27 6 2024
entrez: 27 6 2024
Statut: epublish

Résumé

We describe the design, synthesis, and activity of a potent thiourea-bridged backbone cyclic peptidomimetic known as Clarstatin, comprising a 5-amino acid sequence (Q/D)

Identifiants

pubmed: 38931845
pii: pharmaceutics16060723
doi: 10.3390/pharmaceutics16060723
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : a Kamin grant from the Israel Innovation Authority
ID : 67970

Auteurs

Shira Merzbach (S)

Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel.

Amnon Hoffman (A)

Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel.

Philip Lazarovici (P)

Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel.

Chaim Gilon (C)

Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem 9190401, Israel.

Radgonde Amer (R)

Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.

Classifications MeSH